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- W2953208872 abstract "Chagas disease, caused by the flagellate parasite Trypanosoma cruzi, is a wellknown neglected tropical disease. This parasitic illness affects 6-7 million people and can lead to severe myocarditis and/or complications of the digestive tract. The changes in its epidemiology facilitate co-infection with the Human Immunodeficiency Virus (HIV), making even more difficult the diagnosis and prognosis. The parasitic infection is reactivated in T. cruzi/HIV co-infection, with the appearance of unusual manifestations in the chronic phase and the exacerbation of classical clinical signs. The therapeutic arsenal to treat Chagas disease, in all its clinical forms, is restricted basically to two drugs, benznidazole and nifurtimox. Both drugs are extremely toxic and the therapeutic efficacy is still unclear, making the clinical treatment a huge issue to be solved. Therefore, it seems obvious the necessity of new tangible approaches to combat this illness. In this sense, the repositioning of approved drugs appears as an interesting and viable strategy. The discovery of Human Immunodeficiency Virus Aspartyl Peptidase Inhibitors (HIV-PIs) represented a milestone in the treatment of Acquired Immune Deficiency Syndrome (AIDS) and, concomitantly, a marked reduction in both the incidence and prevalence of important bacterial, fungal and parasitic co-infections was clearly observed. Taking all these findings into consideration, the present review summarizes the promising and beneficial data concerning the effects of HIV-PIs on all the evolutionary forms of T. cruzi and in important steps of the parasite’s life cycle, which highlight their possible application as alternative drugs to treat Chagas disease." @default.
- W2953208872 created "2019-06-27" @default.
- W2953208872 creator A5041089530 @default.
- W2953208872 creator A5051774896 @default.
- W2953208872 creator A5068855331 @default.
- W2953208872 creator A5081994354 @default.
- W2953208872 creator A5091702477 @default.
- W2953208872 date "2019-12-13" @default.
- W2953208872 modified "2023-10-16" @default.
- W2953208872 title "Repositioning of HIV Aspartyl Peptidase Inhibitors for Combating the Neglected Human Pathogen Trypanosoma cruzi" @default.
- W2953208872 cites W1498982714 @default.
- W2953208872 cites W1500352736 @default.
- W2953208872 cites W1663511080 @default.
- W2953208872 cites W1670336810 @default.
- W2953208872 cites W1782287000 @default.
- W2953208872 cites W1964980922 @default.
- W2953208872 cites W1966550751 @default.
- W2953208872 cites W1972043575 @default.
- W2953208872 cites W1973627591 @default.
- W2953208872 cites W1973851226 @default.
- W2953208872 cites W1977645089 @default.
- W2953208872 cites W1977728738 @default.
- W2953208872 cites W1977736130 @default.
- W2953208872 cites W1982361246 @default.
- W2953208872 cites W1982781699 @default.
- W2953208872 cites W1983966903 @default.
- W2953208872 cites W1987565779 @default.
- W2953208872 cites W1989520304 @default.
- W2953208872 cites W1990956809 @default.
- W2953208872 cites W1991150334 @default.
- W2953208872 cites W1991727240 @default.
- W2953208872 cites W1992503089 @default.
- W2953208872 cites W1993263198 @default.
- W2953208872 cites W1997203587 @default.
- W2953208872 cites W1997784624 @default.
- W2953208872 cites W1998184935 @default.
- W2953208872 cites W1998455345 @default.
- W2953208872 cites W2000881860 @default.
- W2953208872 cites W2003578744 @default.
- W2953208872 cites W2003887174 @default.
- W2953208872 cites W2004917117 @default.
- W2953208872 cites W2006594180 @default.
- W2953208872 cites W2007016779 @default.
- W2953208872 cites W2007226778 @default.
- W2953208872 cites W2007608479 @default.
- W2953208872 cites W2008387107 @default.
- W2953208872 cites W2010344849 @default.
- W2953208872 cites W2010634632 @default.
- W2953208872 cites W2011060686 @default.
- W2953208872 cites W2014956822 @default.
- W2953208872 cites W2021822101 @default.
- W2953208872 cites W2024789710 @default.
- W2953208872 cites W2025130434 @default.
- W2953208872 cites W2026518633 @default.
- W2953208872 cites W2026984235 @default.
- W2953208872 cites W2027443714 @default.
- W2953208872 cites W2027503456 @default.
- W2953208872 cites W2031109520 @default.
- W2953208872 cites W2034317507 @default.
- W2953208872 cites W2034793318 @default.
- W2953208872 cites W2035095394 @default.
- W2953208872 cites W2035491154 @default.
- W2953208872 cites W2036084302 @default.
- W2953208872 cites W2036884568 @default.
- W2953208872 cites W2037257307 @default.
- W2953208872 cites W2039182387 @default.
- W2953208872 cites W2040205289 @default.
- W2953208872 cites W2041729187 @default.
- W2953208872 cites W2043059003 @default.
- W2953208872 cites W2045390653 @default.
- W2953208872 cites W2047498253 @default.
- W2953208872 cites W2048636029 @default.
- W2953208872 cites W2049261142 @default.
- W2953208872 cites W2049488727 @default.
- W2953208872 cites W2053026504 @default.
- W2953208872 cites W2057815635 @default.
- W2953208872 cites W2064919526 @default.
- W2953208872 cites W2066371247 @default.
- W2953208872 cites W2067036095 @default.
- W2953208872 cites W2068696470 @default.
- W2953208872 cites W2069553309 @default.
- W2953208872 cites W2070697768 @default.
- W2953208872 cites W2076004445 @default.
- W2953208872 cites W2078324192 @default.
- W2953208872 cites W2078646793 @default.
- W2953208872 cites W2079645565 @default.
- W2953208872 cites W2080638408 @default.
- W2953208872 cites W2081270579 @default.
- W2953208872 cites W2083195707 @default.
- W2953208872 cites W2088941184 @default.
- W2953208872 cites W2091837929 @default.
- W2953208872 cites W2092297057 @default.
- W2953208872 cites W2095464015 @default.
- W2953208872 cites W2096328589 @default.
- W2953208872 cites W2103941030 @default.
- W2953208872 cites W2106256128 @default.
- W2953208872 cites W2108075675 @default.
- W2953208872 cites W2110905825 @default.