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• W2953212384 abstract "Lipid nanoparticles are used widely as anticancer drug and gene delivery systems. Internalizing into the target cell is a prerequisite for the proper activity of many nanoparticulate drugs. We show here, that the lipid composition of a nanoparticle affects its ability to internalize into triple-negative breast cancer cells. The lipid headgroup had the greatest effect on enhancing cellular uptake compared to other segments of the molecule. Having a receptor-targeted headgroup induced the greatest increase in cellular uptake, followed by cationic amine headgroups, both being superior to neutral (zwitterion) phosphatidylcholine or to negatively-charged headgroups. The lipid tails also affected the magnitude of cellular uptake. Longer acyl chains facilitated greater liposomal cellular uptake compared to shorter tails, 18:0 > 16:0 > 14:0. When having the same lipid tail length, unsaturated lipids were superior to saturated ones, 18:1 > 18:0. Interestingly, liposomes composed of phospholipids having 14:0 or 12:0-carbon-long-tails, such as DMPC and DLPC, decreased cell viability in a concertation dependent manner, due to a destabilizing effect these lipids had on the cancer cell membrane. Contrarily, liposomes composed of phospholipids having longer carbon tails (16:0 and 18:0), such as DPPC and HSPC, enhanced cancer cell proliferation. This effect is attributed to the integration of the exogenous liposomal lipids into the cancer-cell membrane, supporting the proliferation process. Cholesterol is a common lipid additive in nanoscale formulations, rigidifying the membrane and stabilizing its structure. Liposomes composed of DMPC (14:0) showed increased cellular uptake when enriched with cholesterol, both by endocytosis and by fusion. Contrarily, the effect of cholesterol on HSPC (18:0) liposomal uptake was minimal. Furthermore, the concentration of nanoparticles in solution affected their cellular uptake. The higher the concentration of nanoparticles the greater the absolute number of nanoparticles taken up per cell. However, the efficiency of nanoparticle uptake, i.e. the percent of nanoparticles taken up by cells, decreased as the concentration of nanoparticles increased. This study demonstrates that tuning the lipid composition and concentration of nanoscale drug delivery systems can be leveraged to modulate their cellular uptake." @default.
• W2953212384 created "2019-06-27" @default.
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• W2953212384 date "2019-08-01" @default.
• W2953212384 modified "2023-10-16" @default.
• W2953212384 title "Tailoring the lipid composition of nanoparticles modulates their cellular uptake and affects the viability of triple negative breast cancer cells" @default.
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• W2953212384 cites W1964779269 @default.
• W2953212384 cites W1965063429 @default.
• W2953212384 cites W1967838912 @default.
• W2953212384 cites W1970239046 @default.
• W2953212384 cites W1972180606 @default.
• W2953212384 cites W1973108551 @default.
• W2953212384 cites W1975581964 @default.
• W2953212384 cites W1979486580 @default.
• W2953212384 cites W1983519686 @default.
• W2953212384 cites W1989230986 @default.
• W2953212384 cites W1989575919 @default.
• W2953212384 cites W1997731002 @default.
• W2953212384 cites W2003110090 @default.
• W2953212384 cites W2008028087 @default.
• W2953212384 cites W2008718396 @default.
• W2953212384 cites W2014349355 @default.
• W2953212384 cites W2016235845 @default.
• W2953212384 cites W2018180334 @default.
• W2953212384 cites W2020845336 @default.
• W2953212384 cites W2022402915 @default.
• W2953212384 cites W2022765714 @default.
• W2953212384 cites W2031813810 @default.
• W2953212384 cites W2032038194 @default.
• W2953212384 cites W2032760352 @default.
• W2953212384 cites W2036536263 @default.
• W2953212384 cites W2036811391 @default.
• W2953212384 cites W2037134420 @default.
• W2953212384 cites W2037572151 @default.
• W2953212384 cites W2040071171 @default.
• W2953212384 cites W2040566502 @default.
• W2953212384 cites W2041771455 @default.
• W2953212384 cites W2058865733 @default.
• W2953212384 cites W2059010575 @default.
• W2953212384 cites W2067294550 @default.
• W2953212384 cites W2068868056 @default.
• W2953212384 cites W2078761335 @default.
• W2953212384 cites W2078800133 @default.
• W2953212384 cites W2080774121 @default.
• W2953212384 cites W2088536552 @default.
• W2953212384 cites W2093359612 @default.
• W2953212384 cites W2094305477 @default.
• W2953212384 cites W2095156612 @default.
• W2953212384 cites W2107457780 @default.
• W2953212384 cites W2117630026 @default.
• W2953212384 cites W2121945369 @default.
• W2953212384 cites W2126020016 @default.
• W2953212384 cites W2134992227 @default.
• W2953212384 cites W2139126860 @default.
• W2953212384 cites W2140895387 @default.
• W2953212384 cites W2143743183 @default.
• W2953212384 cites W2152366705 @default.
• W2953212384 cites W2235523093 @default.
• W2953212384 cites W2300552860 @default.
• W2953212384 cites W2315544737 @default.
• W2953212384 cites W2318910005 @default.
• W2953212384 cites W2329341278 @default.
• W2953212384 cites W2442310462 @default.
• W2953212384 cites W2477103182 @default.
• W2953212384 cites W2554387513 @default.
• W2953212384 cites W2735689337 @default.
• W2953212384 cites W2751108724 @default.
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• W2953212384 doi "https://doi.org/10.1016/j.jconrel.2019.06.025" @default.
• W2953212384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6660975" @default.
• W2953212384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31238049" @default.
• W2953212384 hasPublicationYear "2019" @default.
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