Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953219562> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2953219562 endingPage "1511" @default.
- W2953219562 startingPage "1505" @default.
- W2953219562 abstract "Therapeutic effects of in vivo gene therapy, which aims to treat diseases by administering therapeutic genes to patients, are obtained via proteins expressed from the gene administered. Therefore, to optimize the therapeutic effects of such therapy, it is important to control not only the tissue distribution of gene vectors but also that of proteins expressed from the vector. Studies using protein pharmaceuticals have clearly demonstrated that the therapeutic effect depends largely on the spatiotemporal distribution of proteins, such as area under the curve and mean residence time. These results strongly suggest that precise control of the spatiotemporal distribution of proteins increases the efficacy of in vivo gene therapy. Based on these considerations, we tried to increase the therapeutic effect of plasmid DNA-based gene therapy by controlling the profile of proteins expressed form vectors. To increase the residence time of proteins, we developed plasmids with few CpG motifs and achieved sustained expression of proteins at therapeutic levels for as long as several months. Sustained expression of murine interferon γ was highly effective in inhibiting metastatic tumor growth and atopic dermatitis in mouse models. Thus, designing plasmid vectors is a promising approach not only to controlling the spatiotemporal distribution of proteins, but also to increasing the therapeutic potency of in vivo gene therapy." @default.
- W2953219562 created "2019-06-27" @default.
- W2953219562 creator A5028043688 @default.
- W2953219562 creator A5035791716 @default.
- W2953219562 creator A5071041099 @default.
- W2953219562 date "2010-11-01" @default.
- W2953219562 modified "2023-09-23" @default.
- W2953219562 title "Optimization of Gene Therapy Effect by Spaciotemporal Control of Expressed Proteins" @default.
- W2953219562 cites W1860174057 @default.
- W2953219562 cites W1967686432 @default.
- W2953219562 cites W1978507399 @default.
- W2953219562 cites W1995080846 @default.
- W2953219562 cites W1999358069 @default.
- W2953219562 cites W1999531505 @default.
- W2953219562 cites W2000105955 @default.
- W2953219562 cites W2019465287 @default.
- W2953219562 cites W2021693767 @default.
- W2953219562 cites W2024384131 @default.
- W2953219562 cites W2034629713 @default.
- W2953219562 cites W2050736899 @default.
- W2953219562 cites W2058067959 @default.
- W2953219562 cites W2060306433 @default.
- W2953219562 cites W2079584322 @default.
- W2953219562 cites W2094044907 @default.
- W2953219562 cites W2117318887 @default.
- W2953219562 cites W2118887202 @default.
- W2953219562 cites W2138118556 @default.
- W2953219562 cites W2149556394 @default.
- W2953219562 cites W2151165319 @default.
- W2953219562 cites W2320147764 @default.
- W2953219562 doi "https://doi.org/10.1248/yakushi.130.1505" @default.
- W2953219562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21048410" @default.
- W2953219562 hasPublicationYear "2010" @default.
- W2953219562 type Work @default.
- W2953219562 sameAs 2953219562 @default.
- W2953219562 citedByCount "1" @default.
- W2953219562 crossrefType "journal-article" @default.
- W2953219562 hasAuthorship W2953219562A5028043688 @default.
- W2953219562 hasAuthorship W2953219562A5035791716 @default.
- W2953219562 hasAuthorship W2953219562A5071041099 @default.
- W2953219562 hasBestOaLocation W29532195621 @default.
- W2953219562 hasConcept C104317684 @default.
- W2953219562 hasConcept C111599444 @default.
- W2953219562 hasConcept C140173407 @default.
- W2953219562 hasConcept C150194340 @default.
- W2953219562 hasConcept C190727270 @default.
- W2953219562 hasConcept C207001950 @default.
- W2953219562 hasConcept C22744801 @default.
- W2953219562 hasConcept C40767141 @default.
- W2953219562 hasConcept C43953973 @default.
- W2953219562 hasConcept C54355233 @default.
- W2953219562 hasConcept C70721500 @default.
- W2953219562 hasConcept C86803240 @default.
- W2953219562 hasConcept C92087593 @default.
- W2953219562 hasConcept C98274493 @default.
- W2953219562 hasConceptScore W2953219562C104317684 @default.
- W2953219562 hasConceptScore W2953219562C111599444 @default.
- W2953219562 hasConceptScore W2953219562C140173407 @default.
- W2953219562 hasConceptScore W2953219562C150194340 @default.
- W2953219562 hasConceptScore W2953219562C190727270 @default.
- W2953219562 hasConceptScore W2953219562C207001950 @default.
- W2953219562 hasConceptScore W2953219562C22744801 @default.
- W2953219562 hasConceptScore W2953219562C40767141 @default.
- W2953219562 hasConceptScore W2953219562C43953973 @default.
- W2953219562 hasConceptScore W2953219562C54355233 @default.
- W2953219562 hasConceptScore W2953219562C70721500 @default.
- W2953219562 hasConceptScore W2953219562C86803240 @default.
- W2953219562 hasConceptScore W2953219562C92087593 @default.
- W2953219562 hasConceptScore W2953219562C98274493 @default.
- W2953219562 hasIssue "11" @default.
- W2953219562 hasLocation W29532195621 @default.
- W2953219562 hasLocation W29532195622 @default.
- W2953219562 hasOpenAccess W2953219562 @default.
- W2953219562 hasPrimaryLocation W29532195621 @default.
- W2953219562 hasRelatedWork W1565635735 @default.
- W2953219562 hasRelatedWork W2000695783 @default.
- W2953219562 hasRelatedWork W2009966535 @default.
- W2953219562 hasRelatedWork W2038986915 @default.
- W2953219562 hasRelatedWork W2138450564 @default.
- W2953219562 hasRelatedWork W2336332791 @default.
- W2953219562 hasRelatedWork W2371875333 @default.
- W2953219562 hasRelatedWork W2397865238 @default.
- W2953219562 hasRelatedWork W2429647855 @default.
- W2953219562 hasRelatedWork W4251196660 @default.
- W2953219562 hasVolume "130" @default.
- W2953219562 isParatext "false" @default.
- W2953219562 isRetracted "false" @default.
- W2953219562 magId "2953219562" @default.
- W2953219562 workType "article" @default.