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- W2953223831 abstract "Significance Integrins are adhesion receptors linking cells to their environment, which function as sensors of physical and chemical information to regulate development, immune response, and vascular function. How integrins receive and transduce directional forces including flow or tissue tension has remained elusive. We used polarization-based microscopy techniques to discover that activated αVβ3 integrins are aligned with one another in focal adhesions in migrating fibroblasts. Integrin coalignment is sensitive to mechanical resistance of its ligand and coupling to a dynamic F-actin cytoskeleton, consistent with the “cytoskeleton force model” for integrin activation. Our work suggests that activated integrins are actively ordered at the molecular scale by cellular forces, which may underlie their ability to sense directional forces in their environment to mediate critical functions." @default.
- W2953223831 created "2019-06-27" @default.
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- W2953223831 date "2017-10-03" @default.
- W2953223831 modified "2023-10-17" @default.
- W2953223831 title "Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions" @default.
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- W2953223831 doi "https://doi.org/10.1073/pnas.1701136114" @default.
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