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- W2953236838 endingPage "e1007213" @default.
- W2953236838 startingPage "e1007213" @default.
- W2953236838 abstract "Animals integrate external cues with information about internal conditions such as metabolic state to execute the appropriate behavioral and developmental decisions. Information about food quality and quantity is assessed by the intestine and transmitted to modulate neuronal functions via mechanisms that are not fully understood. The conserved Target of Rapamycin complex 2 (TORC2) controls multiple processes in response to cellular stressors and growth factors. Here we show that TORC2 coordinates larval development and adult behaviors in response to environmental cues and feeding state in the bacterivorous nematode C. elegans. During development, pheromone, bacterial food, and temperature regulate expression of the daf-7 TGF-β and daf-28 insulin-like peptide in sensory neurons to promote a binary decision between reproductive growth and entry into the alternate dauer larval stage. We find that TORC2 acts in the intestine to regulate neuronal expression of both daf-7 and daf-28, which together reflect bacterial-diet dependent feeding status, thus providing a mechanism for integration of food signals with external cues in the regulation of neuroendocrine gene expression. In the adult, TORC2 similarly acts in the intestine to modulate food-regulated foraging behaviors via a PDF-2/PDFR-1 neuropeptide signaling-dependent pathway. We also demonstrate that genetic variation affects food-dependent larval and adult phenotypes, and identify quantitative trait loci (QTL) associated with these traits. Together, these results suggest that TORC2 acts as a hub for communication of feeding state information from the gut to the brain, thereby contributing to modulation of neuronal function by internal state." @default.
- W2953236838 created "2019-06-27" @default.
- W2953236838 creator A5012857095 @default.
- W2953236838 creator A5029906460 @default.
- W2953236838 creator A5029961526 @default.
- W2953236838 creator A5058144096 @default.
- W2953236838 date "2018-02-07" @default.
- W2953236838 modified "2023-09-29" @default.
- W2953236838 title "Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans" @default.
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