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- W2953238103 endingPage "3626" @default.
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- W2953238103 abstract "Our understanding of translation underpins our capacity to engineer living systems. The canonical start codon (AUG) and a few near-cognates (GUG, UUG) are considered as the 'start codons' for translation initiation in Escherichia coli. Translation is typically not thought to initiate from the 61 remaining codons. Here, we quantified translation initiation of green fluorescent protein and nanoluciferase in E. coli from all 64 triplet codons and across a range of DNA copy number. We detected initiation of protein synthesis above measurement background for 47 codons. Translation from non-canonical start codons ranged from 0.007 to 3% relative to translation from AUG. Translation from 17 non-AUG codons exceeded the highest reported rates of non-cognate codon recognition. Translation initiation from non-canonical start codons may contribute to the synthesis of peptides in both natural and synthetic biological systems." @default.
- W2953238103 created "2019-06-27" @default.
- W2953238103 creator A5018371526 @default.
- W2953238103 creator A5039512729 @default.
- W2953238103 creator A5047829117 @default.
- W2953238103 creator A5058204963 @default.
- W2953238103 creator A5075973438 @default.
- W2953238103 creator A5087304853 @default.
- W2953238103 creator A5088291243 @default.
- W2953238103 creator A5091471463 @default.
- W2953238103 date "2017-02-21" @default.
- W2953238103 modified "2023-10-10" @default.
- W2953238103 title "Measurements of translation initiation from all 64 codons in E. coli" @default.
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