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- W2953249976 abstract "This review continues a general presentation of the principles of stereochemistry with special emphasis on the biomedicinal sciences. Here, we discuss and illustrate the phenomenon of substrate stereoselectivity in biochemistry (endogenous metabolism) and principally in xenobiochemistry or drug metabolism. The review begins with an overview of the stereoselective processes occurring in the biomedicinal sciences. The general rule is for distinct stereoisomers, be they enantiomers or diastereoisomers, to elicit different pharmacological responses (Part 5), to a lesser extent be transported with different efficacies (Part 5), and to be metabolized at different rates (this Part). In other words, biological environments discriminate between stereoisomers both when acting on them and when being acted upon by them. The concept of substrate stereoselectivity describes this phenomenon in endogenous biochemistry and xenobiotic metabolism, as discussed and illustrated in the present Part. The sister concept of product stereoselectivity will be presented in Part 8." @default.
- W2953249976 created "2019-06-27" @default.
- W2953249976 creator A5080796605 @default.
- W2953249976 date "2013-07-01" @default.
- W2953249976 modified "2023-09-23" @default.
- W2953249976 title "Organic Stereochemistry. Part 7" @default.
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- W2953249976 doi "https://doi.org/10.1002/hlca.201200475" @default.
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