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- W2953251663 abstract "Ancient biomolecules from oral and gut microbiome samples have been shown to be preserved in the archaeological record. Studying ancient microbiome communities using metagenomic techniques offers a unique opportunity to reconstruct the evolutionary trajectories of microbial communities through time. DNA accumulates specific damage over time, which could potentially affect taxonomic classification and our ability to accurately reconstruct community assemblages. It is therefore necessary to assess whether ancient DNA (aDNA) damage patterns affect metagenomic taxonomic profiling. Here, we assessed biases in community structure, diversity, species detection, and relative abundance estimates by five popular metagenomic taxonomic classification programs using in silico -generated data sets with and without aDNA damage. Damage patterns had minimal impact on the taxonomic profiles produced by each program, while false-positive rates and biases were intrinsic to each program. Therefore, the most appropriate classification program is one that minimizes the biases related to the questions being addressed." @default.
- W2953251663 created "2019-06-27" @default.
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- W2953251663 date "2018-08-28" @default.
- W2953251663 modified "2023-10-12" @default.
- W2953251663 title "Selection of Appropriate Metagenome Taxonomic Classifiers for Ancient Microbiome Research" @default.
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- W2953251663 doi "https://doi.org/10.1128/msystems.00080-18" @default.
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