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• W2953252110 abstract "RNA performs a diverse array of important functions across all cellular life. These functions include important roles in translation, building translational machinery and maturing messenger RNA. More recent discoveries include the miRNAs and bacterial sRNAs that regulate gene expression, the thermosensors, riboswitches and other cis-regulatory elements that help prokaryotes sense their environment and eukaryotic piRNAs that suppress transposition. However, there can be a long period between the initial discovery of a RNA and determining its function. We present a bioinformatic approach to characterise RNA motifs, which are the central building blocks of RNA structure. These motifs can, in some instances, provide researchers with functional hypotheses for uncharacterised RNAs. Moreover, we introduce a new profile-based database of RNA motifs - RMfam - and illustrate its application for investigating the evolution and functional characterisation of RNA. All the data and scripts associated with this work is available from: https://github.com/ppgardne/RMfam" @default.
• W2953252110 created "2019-06-27" @default.
• W2953252110 creator A5053975788 @default.
• W2953252110 creator A5074792426 @default.
• W2953252110 date "2014-11-06" @default.
• W2953252110 modified "2023-10-16" @default.
• W2953252110 title "Annotating RNA motifs in sequences and alignments" @default.
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• W2953252110 doi "https://doi.org/10.1101/011197" @default.
• W2953252110 hasPublicationYear "2014" @default.
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