FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953260051> ?p ?o ?g. }

• W2953260051 abstract "Abstract We investigated the appearance and progression of disease-relevant signs in the B6. Htt Q111/+ mouse, a genetically precise model of the mutation that causes Huntington’s disease (HD). We find that B6. Htt Q111/+ mice are healthy, show no overt signs of central or peripheral inflammation, and no gross motor impairment as late as 12 months of age. Behaviorally, we find that 4-9 month old B6. Htt Q111/+ mice have normal activity levels and show no clear signs of anxiety or depression, but do show clear signs of reduced motivation. The neuronal density, neuronal size, synaptic density and number of glia is normal in B6. Htt Q111/+ striatum, the most vulnerable brain region in HD, up to 12 months of age. Despite this preservation of the synaptic and cellular composition of the striatum, we observe clear progressive, striatal-specific, transcriptional dysregulation and accumulation of neuronal intranuclear inclusions (NIIs). Simulation studies suggest these molecular endpoints are sufficiently robust for future preclinical studies, and that B6. Htt Q111/+ mice are a useful tool for modeling disease-modifying or neuroprotective strategies for disease processes before the onset of overt phenotypes." @default.
• W2953260051 created "2019-06-27" @default.
• W2953260051 creator A5004863367 @default.
• W2953260051 creator A5026981679 @default.
• W2953260051 creator A5034589050 @default.
• W2953260051 creator A5036355734 @default.
• W2953260051 creator A5036479389 @default.
• W2953260051 creator A5039606775 @default.
• W2953260051 creator A5043550325 @default.
• W2953260051 creator A5044919719 @default.
• W2953260051 creator A5045858365 @default.
• W2953260051 creator A5045881823 @default.
• W2953260051 creator A5048591919 @default.
• W2953260051 creator A5055942584 @default.
• W2953260051 creator A5060055505 @default.
• W2953260051 creator A5080796034 @default.
• W2953260051 creator A5082125295 @default.
• W2953260051 creator A5085629786 @default.
• W2953260051 creator A5086013695 @default.
• W2953260051 creator A5086920221 @default.
• W2953260051 creator A5090004774 @default.
• W2953260051 creator A5090089835 @default.
• W2953260051 date "2016-10-14" @default.
• W2953260051 modified "2023-10-18" @default.
• W2953260051 title "Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington’s disease" @default.
• W2953260051 cites W1513618424 @default.
• W2953260051 cites W1631109438 @default.
• W2953260051 cites W1842891513 @default.
• W2953260051 cites W1874092228 @default.
• W2953260051 cites W1964160578 @default.
• W2953260051 cites W1973094248 @default.
• W2953260051 cites W1975932182 @default.
• W2953260051 cites W1977983193 @default.
• W2953260051 cites W1990286385 @default.
• W2953260051 cites W1991480442 @default.
• W2953260051 cites W1991686179 @default.
• W2953260051 cites W1995119071 @default.
• W2953260051 cites W2004767475 @default.
• W2953260051 cites W2007024808 @default.
• W2953260051 cites W2016460575 @default.
• W2953260051 cites W2034823585 @default.
• W2953260051 cites W2062682951 @default.
• W2953260051 cites W2082056883 @default.
• W2953260051 cites W2087820899 @default.
• W2953260051 cites W2091011066 @default.
• W2953260051 cites W2092310066 @default.
• W2953260051 cites W2104117687 @default.
• W2953260051 cites W2111158619 @default.
• W2953260051 cites W2113011235 @default.
• W2953260051 cites W2113661629 @default.
• W2953260051 cites W2114104545 @default.
• W2953260051 cites W2115999215 @default.
• W2953260051 cites W2118546680 @default.
• W2953260051 cites W2121642311 @default.
• W2953260051 cites W2122825543 @default.
• W2953260051 cites W2124063051 @default.
• W2953260051 cites W2130410032 @default.
• W2953260051 cites W2133243301 @default.
• W2953260051 cites W2134401364 @default.
• W2953260051 cites W2142180132 @default.
• W2953260051 cites W2142209350 @default.
• W2953260051 cites W2143116460 @default.
• W2953260051 cites W2146124002 @default.
• W2953260051 cites W2153592313 @default.
• W2953260051 cites W2163987346 @default.
• W2953260051 cites W2165944043 @default.
• W2953260051 cites W2167279371 @default.
• W2953260051 cites W2168133967 @default.
• W2953260051 cites W2171401313 @default.
• W2953260051 cites W2260772890 @default.
• W2953260051 cites W2274495055 @default.
• W2953260051 cites W2464671728 @default.
• W2953260051 cites W4251369530 @default.
• W2953260051 cites W4254687493 @default.
• W2953260051 doi "https://doi.org/10.1101/081109" @default.
• W2953260051 hasPublicationYear "2016" @default.
• W2953260051 type Work @default.
• W2953260051 sameAs 2953260051 @default.
• W2953260051 citedByCount "1" @default.
• W2953260051 countsByYear W29532600512016 @default.
• W2953260051 crossrefType "posted-content" @default.
• W2953260051 hasAuthorship W2953260051A5004863367 @default.
• W2953260051 hasAuthorship W2953260051A5026981679 @default.
• W2953260051 hasAuthorship W2953260051A5034589050 @default.
• W2953260051 hasAuthorship W2953260051A5036355734 @default.
• W2953260051 hasAuthorship W2953260051A5036479389 @default.
• W2953260051 hasAuthorship W2953260051A5039606775 @default.
• W2953260051 hasAuthorship W2953260051A5043550325 @default.
• W2953260051 hasAuthorship W2953260051A5044919719 @default.
• W2953260051 hasAuthorship W2953260051A5045858365 @default.
• W2953260051 hasAuthorship W2953260051A5045881823 @default.
• W2953260051 hasAuthorship W2953260051A5048591919 @default.
• W2953260051 hasAuthorship W2953260051A5055942584 @default.
• W2953260051 hasAuthorship W2953260051A5060055505 @default.
• W2953260051 hasAuthorship W2953260051A5080796034 @default.
• W2953260051 hasAuthorship W2953260051A5082125295 @default.
• W2953260051 hasAuthorship W2953260051A5085629786 @default.
• W2953260051 hasAuthorship W2953260051A5086013695 @default.
• W2953260051 hasAuthorship W2953260051A5086920221 @default.
• W2953260051 hasAuthorship W2953260051A5090004774 @default.

• next