FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953261773> ?p ?o ?g. }

• W2953261773 endingPage "1089" @default.
• W2953261773 startingPage "1077" @default.
• W2953261773 abstract "Oxidative stress and chronic inflammation in arterial walls have been implicated in intracranial aneurysm (IA) formation and rupture. Dimethyl fumarate (DMF) exhibits immunomodulatory properties, partly via activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway which reduces oxidative stress by inducing the antioxidant response element (ARE). This study evaluated the effects of DMF both in vitro, using tumor necrosis factor (TNF)-α-treated vascular smooth muscle cells (VSMC), and in vivo, using a murine elastase model to induce aneurysm formation. The mice were treated with either DMF at 100 mg/kg/day P.O. or vehicle for two weeks. DMF treatment protected VSMCs from TNF-α-induced inflammation as demonstrated by its downregulation of cytokines and upregulation of Nrf2 and smooth muscle cell markers. At higher doses, DMF also inhibited the pro-proliferative action of TNF-α by increasing apoptosis which protected the cells from aponecrosis. In mice, DMF treatment significantly decreased the incidence of aneurysm formation and rupture, at the same time increasing Nrf2 levels. DMF demonstrated a neuroprotective effect in mice with a resultant inhibition of oxidative stress, inflammation, and fibrosis in the cerebrovasculature. This suggests a potential role for DMF as a rescue therapy for patients at risk for formation and rupture of IAs." @default.
• W2953261773 created "2019-06-27" @default.
• W2953261773 creator A5001224623 @default.
• W2953261773 creator A5010894586 @default.
• W2953261773 creator A5012844408 @default.
• W2953261773 creator A5045596055 @default.
• W2953261773 creator A5054411124 @default.
• W2953261773 creator A5057087677 @default.
• W2953261773 creator A5059146591 @default.
• W2953261773 creator A5080210179 @default.
• W2953261773 creator A5080363526 @default.
• W2953261773 creator A5082070342 @default.
• W2953261773 date "2019-06-20" @default.
• W2953261773 modified "2023-09-27" @default.
• W2953261773 title "Treatment with dimethyl fumarate reduces the formation and rupture of intracranial aneurysms: Role of Nrf2 activation" @default.
• W2953261773 cites W1157059961 @default.
• W2953261773 cites W1754156123 @default.
• W2953261773 cites W1921673750 @default.
• W2953261773 cites W1927891329 @default.
• W2953261773 cites W1969418532 @default.
• W2953261773 cites W1972403093 @default.
• W2953261773 cites W1976795428 @default.
• W2953261773 cites W1978094617 @default.
• W2953261773 cites W1980659881 @default.
• W2953261773 cites W1995089232 @default.
• W2953261773 cites W2003910006 @default.
• W2953261773 cites W2011356144 @default.
• W2953261773 cites W2015191281 @default.
• W2953261773 cites W2015392958 @default.
• W2953261773 cites W2028105543 @default.
• W2953261773 cites W2047499088 @default.
• W2953261773 cites W2048760313 @default.
• W2953261773 cites W2056843369 @default.
• W2953261773 cites W2064918830 @default.
• W2953261773 cites W2071198822 @default.
• W2953261773 cites W2077801689 @default.
• W2953261773 cites W2077895679 @default.
• W2953261773 cites W2090551406 @default.
• W2953261773 cites W2096453387 @default.
• W2953261773 cites W2097593378 @default.
• W2953261773 cites W2099309899 @default.
• W2953261773 cites W2101283650 @default.
• W2953261773 cites W2108972511 @default.
• W2953261773 cites W2124172558 @default.
• W2953261773 cites W2128622802 @default.
• W2953261773 cites W2141611253 @default.
• W2953261773 cites W2152100400 @default.
• W2953261773 cites W2158147889 @default.
• W2953261773 cites W2158696025 @default.
• W2953261773 cites W2160814598 @default.
• W2953261773 cites W2163039160 @default.
• W2953261773 cites W2164072240 @default.
• W2953261773 cites W2167941678 @default.
• W2953261773 cites W2168270559 @default.
• W2953261773 cites W2257141517 @default.
• W2953261773 cites W2336862132 @default.
• W2953261773 cites W2341104866 @default.
• W2953261773 cites W2398346487 @default.
• W2953261773 cites W2411727429 @default.
• W2953261773 cites W2477545080 @default.
• W2953261773 cites W2495156620 @default.
• W2953261773 cites W2518578718 @default.
• W2953261773 cites W2564947101 @default.
• W2953261773 cites W2756184308 @default.
• W2953261773 cites W2767982908 @default.
• W2953261773 cites W2794813666 @default.
• W2953261773 cites W952491933 @default.
• W2953261773 doi "https://doi.org/10.1177/0271678x19858888" @default.
• W2953261773 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7181091" @default.
• W2953261773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31220996" @default.
• W2953261773 hasPublicationYear "2019" @default.
• W2953261773 type Work @default.
• W2953261773 sameAs 2953261773 @default.
• W2953261773 citedByCount "19" @default.
• W2953261773 countsByYear W29532617732019 @default.
• W2953261773 countsByYear W29532617732020 @default.
• W2953261773 countsByYear W29532617732021 @default.
• W2953261773 countsByYear W29532617732022 @default.
• W2953261773 countsByYear W29532617732023 @default.
• W2953261773 crossrefType "journal-article" @default.
• W2953261773 hasAuthorship W2953261773A5001224623 @default.
• W2953261773 hasAuthorship W2953261773A5010894586 @default.
• W2953261773 hasAuthorship W2953261773A5012844408 @default.
• W2953261773 hasAuthorship W2953261773A5045596055 @default.
• W2953261773 hasAuthorship W2953261773A5054411124 @default.
• W2953261773 hasAuthorship W2953261773A5057087677 @default.
• W2953261773 hasAuthorship W2953261773A5059146591 @default.
• W2953261773 hasAuthorship W2953261773A5080210179 @default.
• W2953261773 hasAuthorship W2953261773A5080363526 @default.
• W2953261773 hasAuthorship W2953261773A5082070342 @default.
• W2953261773 hasBestOaLocation W29532617731 @default.
• W2953261773 hasConcept C104317684 @default.
• W2953261773 hasConcept C127561419 @default.
• W2953261773 hasConcept C134018914 @default.
• W2953261773 hasConcept C142724271 @default.
• W2953261773 hasConcept C150903083 @default.
• W2953261773 hasConcept C17991360 @default.
• W2953261773 hasConcept C185592680 @default.

• next