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- W2953263493 endingPage "2839" @default.
- W2953263493 startingPage "2839" @default.
- W2953263493 abstract "Chimeric antigen receptor (CAR)-engineered T lymphocytes (CAR Ts) produced impressive clinical results against selected hematological malignancies, but the extension of CAR T cell therapy to the challenging field of solid tumors has not, so far, replicated similar clinical outcomes. Many efforts are currently dedicated to improve the efficacy and safety of CAR-based adoptive immunotherapies, including application against solid tumors. A promising approach is CAR engineering of immune effectors different from αβT lymphocytes. Herein we reviewed biological features, therapeutic potential, and safety of alternative effectors to conventional CAR T cells: γδT, natural killer (NK), NKT, or cytokine-induced killer (CIK) cells. The intrinsic CAR-independent antitumor activities, safety profile, and ex vivo expansibility of these alternative immune effectors may favorably contribute to the clinical development of CAR strategies. The proper biological features of innate immune response effectors may represent an added value in tumor settings with heterogeneous CAR target expression, limiting the risk of tumor clonal escape. All these properties bring out CAR engineering of alternative immune effectors as a promising integrative option to be explored in future clinical studies." @default.
- W2953263493 created "2019-06-27" @default.
- W2953263493 creator A5007780126 @default.
- W2953263493 creator A5041240875 @default.
- W2953263493 creator A5056702454 @default.
- W2953263493 creator A5067852899 @default.
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- W2953263493 creator A5085680955 @default.
- W2953263493 creator A5086890383 @default.
- W2953263493 creator A5088987115 @default.
- W2953263493 date "2019-06-11" @default.
- W2953263493 modified "2023-10-11" @default.
- W2953263493 title "CAR-Based Strategies beyond T Lymphocytes: Integrative Opportunities for Cancer Adoptive Immunotherapy" @default.
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