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- W2953267954 abstract "Adenosine receptors (ARs) and P2Y receptors for purine and pyrimidine nucleotides have widespread distribution and regulate countless physiological processes. Various synthetic ligands are in clinical trials for treatment of inflammatory diseases, pain, cancer, thrombosis, ischemia, and other conditions. The methanocarba (bicyclo[3.1.0]hexane) ring system as a rigid substitution for ribose, which maintains either a North (N) or South (S) conformation, tends to preserve or enhance the potency and/or selectivity for certain receptor subtypes. This review summarizes recent developments in the synthetic approaches to these biologically important nucleoside and nucleotide analogues." @default.
- W2953267954 created "2019-06-27" @default.
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- W2953267954 date "2013-06-03" @default.
- W2953267954 modified "2023-09-26" @default.
- W2953267954 title "ChemInform Abstract: Methanocarba Ring as a Ribose Modification in Ligands of G Protein Coupled Purine and Pyrimidine Receptors: Synthetic Approaches" @default.
- W2953267954 cites W2052158699 @default.
- W2953267954 doi "https://doi.org/10.1002/chin.201325202" @default.
- W2953267954 hasPublicationYear "2013" @default.
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