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- W2953273419 abstract "Summary statement We report the presence of senescent cells in several transient structures in developing amphibian and teleost fish, suggesting novel mechanisms of morphogenesis that appeared early in vertebrate evolution. Abstract Senescence represents a mechanism to avoid undesired cell proliferation that plays a role in tumor suppression, wound healing and embryonic development. In order to gain insight on the evolution of senescence, we looked at its presence in developing axolotls (urodele amphibians) and in zebrafish (teleost fish), which are both anamniotes. Our data indicate that cellular senescence is present in various developing structures in axolotls (pronephros, olfactory nerve fascicles, lateral organs, gums) and in zebrafish (epithelium of the yolk sac and in the lower part of the gut). Senescence was particularly associated with transient structures (pronephros in axolotls & yolk sac in zebrafish) suggesting that it plays a role in the elimination of these tissues. Our data supports the notion that cellular senescence evolved early in vertebrate evolution to influence embryonic development." @default.
- W2953273419 created "2019-06-27" @default.
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- W2953273419 date "2016-12-02" @default.
- W2953273419 modified "2023-10-16" @default.
- W2953273419 title "Senescence gives insights into the morphogenetic evolution of anamniotes" @default.
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- W2953273419 doi "https://doi.org/10.1101/091199" @default.
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