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• W2953277718 abstract "The total synthesis of sandramycin has been accomplished by using a Staudinger/aza-Wittig/diastereoselective Ugi three-component reaction sequence as a key step to obtain a linear pentadepsipeptide. Subsequent [5 + 5] coupling of the penptapeptide, macrolactamization, and introduction of the quinaldin chromophores afforded sandramycin. Dihydroxy and diacetoxy analogues were also prepared, and the cytotoxic activity of these analogues against a range of human cancer cell lines was evaluated." @default.
• W2953277718 created "2019-06-27" @default.
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• W2953277718 date "2013-12-17" @default.
• W2953277718 modified "2023-09-28" @default.
• W2953277718 title "Total Synthesis of Sandramycin and Its Analogues via a Multicomponent Assemblage" @default.
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• W2953277718 doi "https://doi.org/10.1021/ol403319m" @default.
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