Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953282956> ?p ?o ?g. }
- W2953282956 endingPage "76.e7" @default.
- W2953282956 startingPage "64" @default.
- W2953282956 abstract "Type 1 CD8α+ conventional dendritic cells (cDC1s) are required for CD8+ T cell priming but, paradoxically, promote splenic Listeria monocytogenes infection. Using mice with impaired cDC2 function, we ruled out a role for cDC2s in this process and instead discovered an interleukin-10 (IL-10)-dependent cellular crosstalk in the marginal zone (MZ) that promoted bacterial infection. Mice lacking the guanine nucleotide exchange factor DOCK8 or CD19 lost IL-10-producing MZ B cells and were resistant to Listeria. IL-10 increased intracellular Listeria in cDC1s indirectly by reducing inducible nitric oxide synthase expression early after infection and increasing intracellular Listeria in MZ metallophilic macrophages (MMMs). These MMMs trans-infected cDC1s, which, in turn, transported Listeria into the white pulp to prime CD8+ T cells. However, this also facilitated bacterial expansion. Therefore, IL-10-mediated crosstalk between B cells, macrophages, and cDC1s in the MZ promotes both Listeria infection and CD8+ T cell activation." @default.
- W2953282956 created "2019-06-27" @default.
- W2953282956 creator A5002407366 @default.
- W2953282956 creator A5005868865 @default.
- W2953282956 creator A5005904698 @default.
- W2953282956 creator A5008008825 @default.
- W2953282956 creator A5012943931 @default.
- W2953282956 creator A5022682796 @default.
- W2953282956 creator A5025496194 @default.
- W2953282956 creator A5045836594 @default.
- W2953282956 creator A5056036725 @default.
- W2953282956 creator A5059194721 @default.
- W2953282956 creator A5059401787 @default.
- W2953282956 creator A5059434363 @default.
- W2953282956 creator A5062513388 @default.
- W2953282956 creator A5070385508 @default.
- W2953282956 creator A5080521645 @default.
- W2953282956 date "2019-07-01" @default.
- W2953282956 modified "2023-10-15" @default.
- W2953282956 title "IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection" @default.
- W2953282956 cites W1493941926 @default.
- W2953282956 cites W1497894656 @default.
- W2953282956 cites W1506539419 @default.
- W2953282956 cites W1511837220 @default.
- W2953282956 cites W1530666759 @default.
- W2953282956 cites W1573172534 @default.
- W2953282956 cites W158840548 @default.
- W2953282956 cites W1612471968 @default.
- W2953282956 cites W1637461528 @default.
- W2953282956 cites W1824987593 @default.
- W2953282956 cites W1831720205 @default.
- W2953282956 cites W1931750338 @default.
- W2953282956 cites W1970172717 @default.
- W2953282956 cites W1971316795 @default.
- W2953282956 cites W1977099733 @default.
- W2953282956 cites W1985295306 @default.
- W2953282956 cites W1997176275 @default.
- W2953282956 cites W2000727103 @default.
- W2953282956 cites W2006325825 @default.
- W2953282956 cites W2008667095 @default.
- W2953282956 cites W2017870917 @default.
- W2953282956 cites W2017950489 @default.
- W2953282956 cites W2019596936 @default.
- W2953282956 cites W2020744692 @default.
- W2953282956 cites W2030779733 @default.
- W2953282956 cites W2034807686 @default.
- W2953282956 cites W2035325286 @default.
- W2953282956 cites W2036564362 @default.
- W2953282956 cites W2050888742 @default.
- W2953282956 cites W2056628849 @default.
- W2953282956 cites W2057138015 @default.
- W2953282956 cites W2060993079 @default.
- W2953282956 cites W2065362592 @default.
- W2953282956 cites W2069544366 @default.
- W2953282956 cites W2070046036 @default.
- W2953282956 cites W2076534074 @default.
- W2953282956 cites W2077084122 @default.
- W2953282956 cites W2079264478 @default.
- W2953282956 cites W2097006899 @default.
- W2953282956 cites W2097121699 @default.
- W2953282956 cites W2102771576 @default.
- W2953282956 cites W2105798845 @default.
- W2953282956 cites W2107069541 @default.
- W2953282956 cites W2114256385 @default.
- W2953282956 cites W2120778262 @default.
- W2953282956 cites W2123602250 @default.
- W2953282956 cites W2132830324 @default.
- W2953282956 cites W2135169909 @default.
- W2953282956 cites W2136554699 @default.
- W2953282956 cites W2142127956 @default.
- W2953282956 cites W2144418770 @default.
- W2953282956 cites W2150491967 @default.
- W2953282956 cites W2158324692 @default.
- W2953282956 cites W2160578933 @default.
- W2953282956 cites W2167895056 @default.
- W2953282956 cites W2170450008 @default.
- W2953282956 cites W2170657296 @default.
- W2953282956 cites W2179438025 @default.
- W2953282956 cites W2186085368 @default.
- W2953282956 cites W2196638295 @default.
- W2953282956 cites W2216722780 @default.
- W2953282956 cites W2259042290 @default.
- W2953282956 cites W2288720547 @default.
- W2953282956 cites W2408728605 @default.
- W2953282956 cites W2509033762 @default.
- W2953282956 cites W2560397246 @default.
- W2953282956 cites W2585134367 @default.
- W2953282956 cites W2592811885 @default.
- W2953282956 cites W2763279542 @default.
- W2953282956 cites W2771277947 @default.
- W2953282956 cites W2781912964 @default.
- W2953282956 cites W2789400319 @default.
- W2953282956 cites W2808299269 @default.
- W2953282956 cites W2887461902 @default.
- W2953282956 cites W2901221545 @default.
- W2953282956 cites W2918621261 @default.
- W2953282956 doi "https://doi.org/10.1016/j.immuni.2019.05.011" @default.
- W2953282956 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6685086" @default.