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• W2953296912 abstract "Abstract Predicting future brain topography can give insight into neural correlates of aging and neurodegeneration. Due to variability in aging process, it has been challenging to precisely estimate brain topographical change according to aging. Here, we predict age-related brain metabolic change by generating future brain 18 F-Fluorodeoxyglucose PET. A cross-sectional PET dataset of cognitively normal subjects with different age was used to develop a generative model. The model generated PET images using age information and characteristic individual features. Predicted regional metabolic changes were correlated with the real changes obtained by follow-up data. This model was applied to produce a brain metabolism aging movie by generating PET at different ages. Normal population distribution of brain metabolic topography at each age was estimated as well. In addition, a generative model using APOE4 status as well as age as inputs revealed a significant effect of APOE4 status on age-related metabolic changes particularly in the calcarine, lingual cortex, hippocampus and amygdala. It suggested APOE4 could be a factor affecting individual variability in age-related metabolic degeneration in normal elderly. This predictive model may not only be extended to understanding cognitive aging process, but apply to development of a preclinical biomarker for various brain disorders." @default.
• W2953296912 created "2019-06-27" @default.
• W2953296912 creator A5032946641 @default.
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• W2953296912 date "2017-10-11" @default.
• W2953296912 modified "2023-09-23" @default.
• W2953296912 title "Predicting aging of brain metabolic topography using variational autoencoder" @default.
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• W2953296912 doi "https://doi.org/10.1101/200865" @default.
• W2953296912 hasPublicationYear "2017" @default.
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