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- W2953303402 abstract "The use of tetrafluoropyrimidine as a scaffold for the synthesis of 2,4,6-trisubstituted pyrimidine derivatives by three sequential nucleophilic aromatic substitution processes is assessed. Reactions of tetrafluoropyrimidine with various amine nucleophiles followed by a series of nitrogen and oxygen centred nucleophilic species gave a range of 4,6-disubstituted-2,5-difluoropyrimidine systems regioselectively and in good yield. Displacement of a further fluorine atom from representative difluoropyrimidine derivatives proceeded to give trisubstituted pyrimidine derivatives although mixtures of products could be obtained depending upon the substrate." @default.
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- W2953303402 date "2010-08-01" @default.
- W2953303402 modified "2023-10-11" @default.
- W2953303402 title "Trisubstituted pyrimidine derivatives from tetrafluoropyrimidine" @default.
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- W2953303402 doi "https://doi.org/10.1016/j.tet.2010.05.094" @default.
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