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- W2953313006 abstract "Various 6-aryl-4-substituted-2H-pyran-2-one-3-carbonitriles (1a-d) have been synthesized as precursor for the synthesis of 3,4-dihydro-1H-isothiochroman (2a) and benzocycloalkanes (2b-e). Highly functionalized 9-thiaphenanthrene (3b) and phenanthrene (3a) have also been obtained from the reaction of 1c with thiochroman-4-one and 1-tetralone separately. Similarly 4 has been obtained by the ring transformation of 1d by 4-trifluoromethylacetophenone. Most of the synthesized compounds were evaluated for alpha-glucosidase and protein tyrosine phosphatase inhibitory activities. Some of the compounds, 2a, 3a and b and 4 displayed better alpha-glucosidase inhibitory activity compared to standard drug acarbose." @default.
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- W2953313006 date "2005-07-12" @default.
- W2953313006 modified "2023-09-23" @default.
- W2953313006 title "Biaryls and Heterobiaryls as α-Glucosidase and Protein Tyrosine Phosphatase Inhibitors." @default.
- W2953313006 cites W2156709045 @default.
- W2953313006 doi "https://doi.org/10.1002/chin.200528037" @default.
- W2953313006 hasPublicationYear "2005" @default.
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