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- W2953313639 abstract "The first biologically active member and a key intermediate of a new family of simplified bryostatin analogues are synthesized through an optimized esterification–macrotransacetalization strategy. This family incorporates both an ester linkage between C5 and C9 in addition to a C9 t-butyl substituent to mimic the bryostatin A-ring. Importantly, a free C7 alcohol is revealed late in the synthesis, allowing access to numerous C7 derivatized analogues." @default.
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- W2953313639 date "2000-02-01" @default.
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- W2953313639 title "Synthesis and biological evaluation of bryostatin analogues: the role of the A-ring" @default.
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- W2953313639 doi "https://doi.org/10.1016/s0040-4039(99)02195-4" @default.
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