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- W2953316403 abstract "Objective To present a primitive monophasic sarcoma of the mandible in a young male with spindle-cell predominant component and non-specific immunohistochemical phenotype. Uncertain origin sarcomas are a very complex and heterogeneous group of neoplasms, categorized by their undetermined histogenesis and peculiar morphological features; generally associated to a specific translocation. This type of sarcomas has not sufficient clinical and diagnostic information because its low frequency in this site. Case report A 23-year-old male presented with slow-progressive mobility and tooth loss associated with gingival enlargement in the third quadrant. Local examination showed a firm mass of approximately 5 × 4 cm in the body of the mandible. X-ray examination revealed an extensive ill-defined radiolucency on the left side of the mandibular body. CT-scan assessed bone and soft tissue infiltration. Hemimandibulectomy was performed and gross examination consisted of a solid nodular mass. Microscopically a monotonous spindle-cell lesion with fascicular pattern was observed, hypercellular areas and hemangiopericytoid-like vessels were the predominant component. The neoplastic cells displayed pleomorphic nuclear features with vesicular chromatin. A wide immuhohistochemical panel was performed showing reactivity for Calponin, CD68, CD99, Bcl-2, TLE-1, NSE, FLI-1, WT1, PTEN and 40% Ki67 index. Conclusion Despite of the high sensitivity, antibodies are not conclusive for an accurate diagnosis. Molecular techniques were required to establish this entity with great implication in patient management. Complete assesment of undifferentiated sarcomas should include clinical/radiological correlation, histopathology, immunohistochemical staining and genetic confirmation." @default.
- W2953316403 created "2019-06-27" @default.
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- W2953316403 date "2019-07-01" @default.
- W2953316403 modified "2023-10-01" @default.
- W2953316403 title "PRIMARY MANDIBULAR UNDIFFERENTIATED SARCOMA. A CASE REPORT" @default.
- W2953316403 doi "https://doi.org/10.1016/j.oooo.2019.02.163" @default.
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