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• W2953322013 abstract "A series of 6-morpholino-4-aryl-3(2H)-pyridazinone alkanoic acids, their ester and amide derivatives were prepared and tested for their in vivo analgesic activity by using the p-benzoquinone-induced writhing test. The analgesic activity of the compounds 6-morpholino-4-aryl-3(2H)-pyridazinone (6a-b) were comparable but little lower than that of acetyl-salicylic acid (CAS 50-78-2) as an analgesic agent. The 6-morpholino-4-aryl-3(2H)-pyridazinones having a propanoic acid (10a-b), ester (7a) and amides (12a-b, 12d and 12g) as side chains at the position 2 of the pyridazinone ring showed higher activity than the reference compound without gastric ulceration forming potential. All other compounds generally showed higher activity but caused gastric ulceration in the animals." @default.
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• W2953322013 date "2011-12-22" @default.
• W2953322013 modified "2023-09-26" @default.
• W2953322013 title "Synthesis and Analgesic Activity of Some 4,6-Disubstituted-3(2H)-Pyridazinone Derivatives" @default.
• W2953322013 doi "https://doi.org/10.1055/s-0031-1296731" @default.
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