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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953358649> ?p ?o ?g. }

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• W2953358649 abstract "We and others have reported that the anticancer activity of L-asparaginase (ASNase) against asparagine synthetase (ASNS)-positive cell types requires ASNase glutaminase activity, whereas anticancer activity against ASNS-negative cell types does not. Here, we attempted to disentangle the relationship between asparagine metabolism, glutamine metabolism, and downstream pathways that modulate cell viability by testing the hypothesis that ASNase anticancer activity is based on asparagine depletion rather than glutamine depletion per se. We tested ASNase wild-type (ASNaseWT) and its glutaminase-deficient Q59L mutant (ASNaseQ59L) and found that ASNase glutaminase activity contributed to durable anticancer activity against xenografts of the ASNS-negative Sup-B15 leukemia cell line in NOD/SCID gamma mice, whereas asparaginase activity alone yielded a mere growth delay. Our findings suggest that ASNase glutaminase activity is necessary for durable, single-agent anticancer activity in vivo, even against ASNS-negative cancer types." @default.
• W2953358649 created "2019-06-27" @default.
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• W2953358649 date "2019-09-01" @default.
• W2953358649 modified "2023-10-18" @default.
• W2953358649 title "Glutaminase Activity of <scp>L</scp>-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia" @default.
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• W2953358649 doi "https://doi.org/10.1158/1535-7163.mct-18-1329" @default.
• W2953358649 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6726508" @default.
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