Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953367906> ?p ?o ?g. }
- W2953367906 abstract "Abstract Catalytic asymmetric cycloadditions via transition-metal-containing dipolar intermediates are a powerful tool for synthesizing chiral heterocycles. However, within the field of palladium catalysis, compared with the well-developed normal electron-demand cycloadditions with electrophilic dipolarophiles, a general strategy for inverse electron-demand ones with nucleophilic dipolarophiles remains elusive, due to the inherent linear selectivity in the key palladium-catalyzed intermolecular allylations. Herein, based on the switched regioselectivity of iridium-catalyzed allylations, we achieved two asymmetric [4+2] cycloadditions of vinyl aminoalcohols with aldehydes and β,γ-unsaturated ketones through synergetic iridium and amine catalysis. The activation of vinyl aminoalcohols by iridium catalysts and carbonyls by amine catalysts provide a foundation for the subsequent asymmetric [4+2] cycloadditions of the resulting iridium-containing 1,4-dipoles and (di)enamine dipolarophiles. The former provides a straightforward route to a diverse set of enantio-enriched hydroquinolines bearing chiral quaternary stereocenters, and the later represent an enantio- and diastereodivergent synthesis of chiral hydroquinolines." @default.
- W2953367906 created "2019-06-27" @default.
- W2953367906 creator A5029146832 @default.
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- W2953367906 date "2019-06-20" @default.
- W2953367906 modified "2023-10-12" @default.
- W2953367906 title "Synergetic iridium and amine catalysis enables asymmetric [4+2] cycloadditions of vinyl aminoalcohols with carbonyls" @default.
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- W2953367906 doi "https://doi.org/10.1038/s41467-019-10674-3" @default.
- W2953367906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6586609" @default.
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