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- W2953371003 abstract "Background Lupus nephritis carries high morbidity and mortality and whenever added to neuropsychiatric manifestations lead to more unfavorable prognosis. The current work focused on LN patients comparing them to those without kidney affection, studying their cerebral MRI and its correlation with the histopathological classes of LN and disease activity. Objectives To study the effect of renal affection on the brain in SLE and their clinical significance with early detection and management of such lethal comorbidity Methods Cerebral MRI and MRA were studied in 40 SLE patients without neuropsychiatric manifestation; 20 LN patients with different histopathological classes and 20 patients without kidney affection. Disease activity was assessed for all patients using SLE disease activity index Results Abnormal MRI brain findings were more common in LN patients ”though non significant” (P=0.9). The most common lesions were white matter hyperintense lesions. Number and size of such lesions were significantly higher in LN patients (1.8 fold that of non nephritis, P=0.003 and 0.03, respectively) and positively correlated with urea, creatinine, urinary albumin/creatinine ratio, SLEDAI, ESR, CRP, and grades of renal biopsy and negatively correlated with c3 and c4. cortical atrophy and prepontine space dilatation were also significantly higher in LN patients (P=0.01). Conclusion Asymptomatic MRI brain lesions in LN patients, they are usually clinically significant and correlate to laboratory parameters of LN, grades of renal biopsy, and disease activity independent to age, sex and hypertension. References [1] Pons_Estel GJ, Alarcon GS, Scofield L, Reinlib L, Cooper GS. Understanding the epidemiology and progression of systemic lupus erythematous. Semin Arthritis Rheum2010;39:257-68. Disclosure of Interests None declared" @default.
- W2953371003 created "2019-06-27" @default.
- W2953371003 creator A5070171954 @default.
- W2953371003 date "2019-05-27" @default.
- W2953371003 modified "2023-09-26" @default.
- W2953371003 title "AB0159 SILENT CEREBRAL MRI FINDINGS IN LUPUS NEPHRITIS AND NON NEPHRITIS PATIENTS" @default.
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- W2953371003 doi "https://doi.org/10.1136/annrheumdis-2019-eular.224" @default.
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