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- W2953389024 abstract "Radiotherapeutic drugs and medical imaging agents, although used for different purposes, both benefit from precise targeting. When systemically administered, either would be most useful if designed to find and bind only a tumor, single type of cell, or unique molecular assembly thereon. In this Account, we examine the use of small peptides, natural and synthetic, to create biochemically specific molecular imaging agents and radiotherapeutic pharmaceuticals, discussing three distinct examples. In one project, a small natural peptide known to target members of the bombesin family of receptors was chemically attached to a strong, versatile metal chelator, DO3A, through a series of small-molecule linkers. The linkers powerfully affected not only binding strength for the bombesin receptors, tissue distribution, and tumor uptake in vivo but also receptor subtype specificity. When the assembly is combined with an active metal ion for human trials, the versatility of the DO3A (dodecanetriacetate) chelate affords ..." @default.
- W2953389024 created "2019-06-27" @default.
- W2953389024 creator A5060874288 @default.
- W2953389024 date "2009-11-24" @default.
- W2953389024 modified "2023-09-27" @default.
- W2953389024 title "ChemInform Abstract: Peptide-Targeted Diagnostics and Radiotherapeutics" @default.
- W2953389024 cites W1978465832 @default.
- W2953389024 doi "https://doi.org/10.1002/chin.200947259" @default.
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