Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953390138> ?p ?o ?g. }
- W2953390138 abstract "Glutamate transporter-1 (GLT-1) is a Na+-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS). GLT-1 dysregulation occurs in various neurological diseases including Huntington's disease (HD), Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and epilepsy. Downregulation or dysfunction of GLT-1 has been a common finding across these diseases but how this occurs is still under investigation. This review aims to highlight post-translational regulation of GLT-1 which leads to its downregulation including sumoylation, palmitoylation, nitrosylation, ubiquitination, and subcellular localization. Various therapeutic interventions to restore GLT-1, their proposed mechanism of action and functional effects will be examined as potential treatments to attenuate the neurological symptoms associated with loss or downregulation of GLT-1." @default.
- W2953390138 created "2019-06-27" @default.
- W2953390138 creator A5012744570 @default.
- W2953390138 creator A5050427417 @default.
- W2953390138 date "2019-07-09" @default.
- W2953390138 modified "2023-10-12" @default.
- W2953390138 title "Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target" @default.
- W2953390138 cites W118386170 @default.
- W2953390138 cites W1507443798 @default.
- W2953390138 cites W1508839941 @default.
- W2953390138 cites W1534880720 @default.
- W2953390138 cites W1558654722 @default.
- W2953390138 cites W1629378997 @default.
- W2953390138 cites W1644388421 @default.
- W2953390138 cites W17230872 @default.
- W2953390138 cites W1965044068 @default.
- W2953390138 cites W1968131336 @default.
- W2953390138 cites W1971395905 @default.
- W2953390138 cites W1973055895 @default.
- W2953390138 cites W1975779891 @default.
- W2953390138 cites W1977832158 @default.
- W2953390138 cites W1979456296 @default.
- W2953390138 cites W1979889191 @default.
- W2953390138 cites W1980477426 @default.
- W2953390138 cites W1983568884 @default.
- W2953390138 cites W1985459796 @default.
- W2953390138 cites W1995963726 @default.
- W2953390138 cites W2007872436 @default.
- W2953390138 cites W2012851706 @default.
- W2953390138 cites W2016575029 @default.
- W2953390138 cites W2017349018 @default.
- W2953390138 cites W2021727296 @default.
- W2953390138 cites W2022452742 @default.
- W2953390138 cites W2023104245 @default.
- W2953390138 cites W2024674223 @default.
- W2953390138 cites W2026493164 @default.
- W2953390138 cites W2034539973 @default.
- W2953390138 cites W2040868411 @default.
- W2953390138 cites W2045286159 @default.
- W2953390138 cites W2048370637 @default.
- W2953390138 cites W2048916015 @default.
- W2953390138 cites W2049264566 @default.
- W2953390138 cites W2051808752 @default.
- W2953390138 cites W2052930675 @default.
- W2953390138 cites W2053378951 @default.
- W2953390138 cites W2057323595 @default.
- W2953390138 cites W2060904722 @default.
- W2953390138 cites W2062102510 @default.
- W2953390138 cites W2063262521 @default.
- W2953390138 cites W2068815614 @default.
- W2953390138 cites W2070874094 @default.
- W2953390138 cites W2073918272 @default.
- W2953390138 cites W2079982203 @default.
- W2953390138 cites W2082970207 @default.
- W2953390138 cites W2083204774 @default.
- W2953390138 cites W2085035881 @default.
- W2953390138 cites W2088846224 @default.
- W2953390138 cites W2089745167 @default.
- W2953390138 cites W2092971129 @default.
- W2953390138 cites W2095300799 @default.
- W2953390138 cites W2096577768 @default.
- W2953390138 cites W2096577890 @default.
- W2953390138 cites W2100345329 @default.
- W2953390138 cites W2102086084 @default.
- W2953390138 cites W2104248619 @default.
- W2953390138 cites W2117516401 @default.
- W2953390138 cites W2119774379 @default.
- W2953390138 cites W2121726351 @default.
- W2953390138 cites W2124603852 @default.
- W2953390138 cites W2125056253 @default.
- W2953390138 cites W2133527428 @default.
- W2953390138 cites W2139560421 @default.
- W2953390138 cites W2148815116 @default.
- W2953390138 cites W2158453961 @default.
- W2953390138 cites W2159851687 @default.
- W2953390138 cites W2160644313 @default.
- W2953390138 cites W2161325655 @default.
- W2953390138 cites W2163459810 @default.
- W2953390138 cites W2176548633 @default.
- W2953390138 cites W2213881538 @default.
- W2953390138 cites W2255749509 @default.
- W2953390138 cites W2302083665 @default.
- W2953390138 cites W2326514561 @default.
- W2953390138 cites W2331751401 @default.
- W2953390138 cites W2345601781 @default.
- W2953390138 cites W2346726077 @default.
- W2953390138 cites W2395225545 @default.
- W2953390138 cites W2403978899 @default.
- W2953390138 cites W2517303021 @default.
- W2953390138 cites W2559796913 @default.
- W2953390138 cites W2560345632 @default.
- W2953390138 cites W2564814346 @default.
- W2953390138 cites W2583813967 @default.
- W2953390138 cites W2597762882 @default.
- W2953390138 cites W2598441763 @default.
- W2953390138 cites W2606824156 @default.
- W2953390138 cites W2614010581 @default.
- W2953390138 cites W2630071927 @default.
- W2953390138 cites W2654650727 @default.
- W2953390138 cites W2751287980 @default.