FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953399503> ?p ?o ?g. }

• W2953399503 endingPage "534" @default.
• W2953399503 startingPage "523" @default.
• W2953399503 abstract "The balance between Th17 and Treg cells controls the immune response and is an important regulator of helper T cells acting on autoimmune diseases. Focal cerebral ischemia-reperfusion injury can induce imbalance of Th17/Treg cells in the brain and the peripheral immune system of rats. The aim of this study was to investigate the effect of salidroside (Sal) on the ratio of Th17 and Treg cells in an adult rat model of middle cerebral artery occlusion (MCAO).Forty rats were divided into 4 groups: normal group, sham group, surgery group, and Sal group. After treatment, the neurological deficits in rats were evaluated. Peripheral blood mononuclear cells were isolated and the count of Th17 and Treg cells was detected by flow cytometry. The infarct size and expression of RORγt and Foxp3 were detected in rat brain tissue. Rat spleen cells were isolated, CD4+ T cells were purified by immunomagnetic beads. Treg cells were induced by adding cytokine TGF-β. Th17 cells were induced by adding cytokine IL-6. The expression of STAT-3 was inhibited by SiRNA, and the effect of Sal on the differentiation of Th17/Treg cells was analyzed. The expression levels of IL-6, TNF-α, MCP-1, STAT-3 and NF-κ-B2 proteins were examined.The results show that MCAO can induce an imbalance of Th17 and Treg cells in peripheral blood of rats. Sal treatment can significantly reduce the neurological deficit and infarct size of MCAO rats, reverse the oxidative stress of rat brain tissue, and inhibit the apoptosis of brain cells in MCAO rats. In the brain tissue of MCAO rats, Sal could significantly inhibit the expression of IL-6, TNF-α, MCP-1, STAT-3 and NF-κ-B2. Down-regulation of STAT-3 significantly reversed the therapeutic effects of Sal treatment.Our results indicate that Sal can increase the tolerance of rat brain tissue to ischemia, inhibit cell apoptosis and reduce oxidative stress by targeting STAT-3." @default.
• W2953399503 created "2019-07-12" @default.
• W2953399503 creator A5000230939 @default.
• W2953399503 creator A5025961615 @default.
• W2953399503 creator A5045414725 @default.
• W2953399503 creator A5052703331 @default.
• W2953399503 creator A5055290784 @default.
• W2953399503 date "2021-03-02" @default.
• W2953399503 modified "2023-09-30" @default.
• W2953399503 title "Salidroside regulates imbalance of Th17/Treg and promotes ischemic tolerance by targeting STAT-3 in cerebral ischemia-reperfusion injury" @default.
• W2953399503 cites W1747519355 @default.
• W2953399503 cites W1878828051 @default.
• W2953399503 cites W1948195609 @default.
• W2953399503 cites W1949461279 @default.
• W2953399503 cites W1969611524 @default.
• W2953399503 cites W1981932893 @default.
• W2953399503 cites W1982696151 @default.
• W2953399503 cites W2001835698 @default.
• W2953399503 cites W2024490058 @default.
• W2953399503 cites W2032118844 @default.
• W2953399503 cites W2040322192 @default.
• W2953399503 cites W2041205265 @default.
• W2953399503 cites W2048960835 @default.
• W2953399503 cites W2049089971 @default.
• W2953399503 cites W2058595623 @default.
• W2953399503 cites W2062541991 @default.
• W2953399503 cites W2067226591 @default.
• W2953399503 cites W2071530841 @default.
• W2953399503 cites W2081244566 @default.
• W2953399503 cites W2087260358 @default.
• W2953399503 cites W2093629212 @default.
• W2953399503 cites W2097931810 @default.
• W2953399503 cites W2112505121 @default.
• W2953399503 cites W2131196233 @default.
• W2953399503 cites W2132725516 @default.
• W2953399503 cites W2134093322 @default.
• W2953399503 cites W2135909217 @default.
• W2953399503 cites W2158054048 @default.
• W2953399503 cites W2160083314 @default.
• W2953399503 cites W2232318478 @default.
• W2953399503 cites W237394825 @default.
• W2953399503 cites W2465816926 @default.
• W2953399503 cites W2560946820 @default.
• W2953399503 cites W2619363385 @default.
• W2953399503 doi "https://doi.org/10.5114/aoms.2019.85349" @default.
• W2953399503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7959015" @default.
• W2953399503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33747287" @default.
• W2953399503 hasPublicationYear "2021" @default.
• W2953399503 type Work @default.
• W2953399503 sameAs 2953399503 @default.
• W2953399503 citedByCount "10" @default.
• W2953399503 countsByYear W29533995032022 @default.
• W2953399503 countsByYear W29533995032023 @default.
• W2953399503 crossrefType "journal-article" @default.
• W2953399503 hasAuthorship W2953399503A5000230939 @default.
• W2953399503 hasAuthorship W2953399503A5025961615 @default.
• W2953399503 hasAuthorship W2953399503A5045414725 @default.
• W2953399503 hasAuthorship W2953399503A5052703331 @default.
• W2953399503 hasAuthorship W2953399503A5055290784 @default.
• W2953399503 hasBestOaLocation W29533995031 @default.
• W2953399503 hasConcept C126322002 @default.
• W2953399503 hasConcept C190283241 @default.
• W2953399503 hasConcept C203014093 @default.
• W2953399503 hasConcept C2779526882 @default.
• W2953399503 hasConcept C2779727006 @default.
• W2953399503 hasConcept C2780931953 @default.
• W2953399503 hasConcept C541997718 @default.
• W2953399503 hasConcept C553184892 @default.
• W2953399503 hasConcept C55493867 @default.
• W2953399503 hasConcept C71924100 @default.
• W2953399503 hasConcept C74737994 @default.
• W2953399503 hasConcept C86803240 @default.
• W2953399503 hasConcept C8891405 @default.
• W2953399503 hasConcept C98274493 @default.
• W2953399503 hasConceptScore W2953399503C126322002 @default.
• W2953399503 hasConceptScore W2953399503C190283241 @default.
• W2953399503 hasConceptScore W2953399503C203014093 @default.
• W2953399503 hasConceptScore W2953399503C2779526882 @default.
• W2953399503 hasConceptScore W2953399503C2779727006 @default.
• W2953399503 hasConceptScore W2953399503C2780931953 @default.
• W2953399503 hasConceptScore W2953399503C541997718 @default.
• W2953399503 hasConceptScore W2953399503C553184892 @default.
• W2953399503 hasConceptScore W2953399503C55493867 @default.
• W2953399503 hasConceptScore W2953399503C71924100 @default.
• W2953399503 hasConceptScore W2953399503C74737994 @default.
• W2953399503 hasConceptScore W2953399503C86803240 @default.
• W2953399503 hasConceptScore W2953399503C8891405 @default.
• W2953399503 hasConceptScore W2953399503C98274493 @default.
• W2953399503 hasIssue "2" @default.
• W2953399503 hasLocation W29533995031 @default.
• W2953399503 hasLocation W29533995032 @default.
• W2953399503 hasLocation W29533995033 @default.
• W2953399503 hasOpenAccess W2953399503 @default.
• W2953399503 hasPrimaryLocation W29533995031 @default.
• W2953399503 hasRelatedWork W2036107469 @default.
• W2953399503 hasRelatedWork W2081358646 @default.
• W2953399503 hasRelatedWork W2108574369 @default.
• W2953399503 hasRelatedWork W2356264837 @default.

• next