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• W2953400589 endingPage "278" @default.
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• W2953400589 abstract "Repetitive mild traumatic brain injury (RmTBI) is a prevalent and costly head injury particularly among adolescents. These injuries may result in long-term consequences, especially during this critical period of development. Insomnia and sleeping difficulties are frequently reported following RmTBI and greatly impair recovery. We sought to develop an animal model of exacerbated deficits following RmTBI by disrupting the hypothalamic circadian system. To accomplish this, we conducted RmTBI on adolescent rats that had received neonatal injections of monosodium glutamate (MSG), a known hypothalamic neurotoxin. We then examined behavioral, circadian, and epigenetic changes. MSG treated rats showed lower anxiety-like behaviors and displayed poor short-term working memory. We also showed changes in the morphology of the circadian clock in the suprachiasmatic nucleus (SCN) vasoactive intestinal polypeptide (VIP) immunostaining. VIP optical density in the SCN increased with MSG but decreased with RmTBI. There were changes in the expression of the clock genes and upregulation of the orexin receptors in response to RmTBI. MSG treated rats had longer telomere lengths than controls. Finally, although both MSG and RmTBI alone produced attenuated circadian amplitudes of activity and body temperature, exacerbated deficits were not identified in animals that received MSG and RmTBI. In sum, both MSG and RmTBI can alter behavior, circadian rhythm amplitude, SCN morphology, and gene expression independently, but the effects do not appear to be additive. Specific damage in the hypothalamus and SCN should be considered when patients experience sleeping problems following RmTBI, as this may improve therapeutic strategies." @default.
• W2953400589 created "2019-07-12" @default.
• W2953400589 creator A5012397054 @default.
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• W2953400589 date "2019-08-01" @default.
• W2953400589 modified "2023-09-24" @default.
• W2953400589 title "Investigating the Role of the Hypothalamus in Outcomes to Repetitive Mild Traumatic Brain Injury: Neonatal Monosodium Glutamate Does Not Exacerbate Deficits" @default.
• W2953400589 cites W1789349355 @default.
• W2953400589 cites W1819467863 @default.
• W2953400589 cites W1964160578 @default.
• W2953400589 cites W1971968477 @default.
• W2953400589 cites W1974856022 @default.
• W2953400589 cites W1975653440 @default.
• W2953400589 cites W1976850815 @default.
• W2953400589 cites W1986608768 @default.
• W2953400589 cites W1986738450 @default.
• W2953400589 cites W1986915165 @default.
• W2953400589 cites W1993618423 @default.
• W2953400589 cites W2001391135 @default.
• W2953400589 cites W2002732049 @default.
• W2953400589 cites W2008222156 @default.
• W2953400589 cites W2015902336 @default.
• W2953400589 cites W2017001186 @default.
• W2953400589 cites W2019050835 @default.
• W2953400589 cites W2020540646 @default.
• W2953400589 cites W2021160835 @default.
• W2953400589 cites W2021836517 @default.
• W2953400589 cites W2024032885 @default.
• W2953400589 cites W2036886541 @default.
• W2953400589 cites W2039134132 @default.
• W2953400589 cites W2040381415 @default.
• W2953400589 cites W2041561931 @default.
• W2953400589 cites W2042739149 @default.
• W2953400589 cites W2044686016 @default.
• W2953400589 cites W2049002034 @default.
• W2953400589 cites W2053885070 @default.
• W2953400589 cites W2058311738 @default.
• W2953400589 cites W2068176427 @default.
• W2953400589 cites W2068351868 @default.
• W2953400589 cites W2070711080 @default.
• W2953400589 cites W2071661381 @default.
• W2953400589 cites W2072058015 @default.
• W2953400589 cites W2077010257 @default.
• W2953400589 cites W2083764007 @default.
• W2953400589 cites W2083968589 @default.
• W2953400589 cites W2084625947 @default.
• W2953400589 cites W2094785614 @default.
• W2953400589 cites W2095472576 @default.
• W2953400589 cites W2099009590 @default.
• W2953400589 cites W2100800839 @default.
• W2953400589 cites W2105960590 @default.
• W2953400589 cites W2108244474 @default.
• W2953400589 cites W2131859465 @default.
• W2953400589 cites W2136997701 @default.
• W2953400589 cites W2139482507 @default.
• W2953400589 cites W2140660122 @default.
• W2953400589 cites W2141223988 @default.
• W2953400589 cites W2142195676 @default.
• W2953400589 cites W2146208024 @default.
• W2953400589 cites W2154127252 @default.
• W2953400589 cites W2156421031 @default.
• W2953400589 cites W2158067467 @default.
• W2953400589 cites W2160621707 @default.
• W2953400589 cites W2161581479 @default.
• W2953400589 cites W2163225965 @default.
• W2953400589 cites W2167917782 @default.
• W2953400589 cites W2169355774 @default.
• W2953400589 cites W2170078281 @default.
• W2953400589 cites W2190599599 @default.
• W2953400589 cites W2208667142 @default.
• W2953400589 cites W2272437969 @default.
• W2953400589 cites W2278483058 @default.
• W2953400589 cites W2302280739 @default.
• W2953400589 cites W2306237590 @default.
• W2953400589 cites W2463725636 @default.
• W2953400589 cites W2490965374 @default.
• W2953400589 cites W2517022736 @default.
• W2953400589 cites W2591790119 @default.
• W2953400589 cites W2620702548 @default.
• W2953400589 cites W2625887310 @default.
• W2953400589 cites W2748555635 @default.
• W2953400589 cites W2765565225 @default.
• W2953400589 cites W2767949301 @default.
• W2953400589 cites W2770203404 @default.
• W2953400589 cites W2790337945 @default.
• W2953400589 cites W2807073242 @default.
• W2953400589 cites W2892779344 @default.
• W2953400589 cites W4211107169 @default.
• W2953400589 cites W78858577 @default.
• W2953400589 cites W822968820 @default.
• W2953400589 doi "https://doi.org/10.1016/j.neuroscience.2019.06.022" @default.
• W2953400589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31254543" @default.
• W2953400589 hasPublicationYear "2019" @default.
• W2953400589 type Work @default.

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