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• W2953404211 abstract "In the past years, there have been significant advances in the understanding of how environmental conditions alone or in conjunction with pathogen invasion affect the metabolism of T cells, thereby influencing their activation, differentiation and longevity. Detailed insights of the interlinked processes of activation and metabolism can contribute to major advances in immunotherapies. Naive and memory T cells circulate the body. In a quiescent state with low metabolic demands, they predominantly use oxidative phosphorylation for their energy needs. Recognition of cognate antigen combined with costimulatory signals results in a proliferative burst and effector molecule production, requiring rapid release of energy, achieved via dynamically reprogramming of metabolic pathways. After activation, most T cells succumb to activation induced cell death, but few differentiate into memory T cells. Of note, some memory T cells permanently occupy tissues without circulating. These, tissue resident T cells are predominantly CD8 T cells, maintained in a metabolic state distinct from naïve and circulating memory CD8 T cells with elements similar to effector CD8 T cells but without undergoing proliferative burst or secreting immune mediators. They continually interact with tissue cells as part of an immune surveillance network, are well adapted to the tissues they have made their home and where they may encounter different metabolic environments. In this review, we will discuss recent insights in metabolic characteristics of CD8 T cell biology, with emphasis on tissue resident CD8 T cells at the epithelial barriers." @default.
• W2953404211 created "2019-07-12" @default.
• W2953404211 creator A5078799040 @default.
• W2953404211 creator A5082073030 @default.
• W2953404211 date "2019-07-17" @default.
• W2953404211 modified "2023-09-30" @default.
• W2953404211 title "Dynamic Metabolic State of Tissue Resident CD8 T Cells" @default.
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• W2953404211 doi "https://doi.org/10.3389/fimmu.2019.01683" @default.
• W2953404211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6650586" @default.

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