FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953408035> ?p ?o ?g. }

• W2953408035 endingPage "109389" @default.
• W2953408035 startingPage "109389" @default.
• W2953408035 abstract "Simvastatin (SV), as an hypocholesterolaemic drug, has been detected in various aquatic environment. However, limited information is available on the effects of SV on freshwater invertebrates. In the present study, we investigated the toxic effects of SV on Daphnia. magna (D. magna) through measuring the physiological changes (e.g., survival, growth rate, and reproduction) in a 21-d chronic toxicity test We also determined the expression of seven detoxification and reproduction-related genes (i.e. HR96, P-gp, CYP360A8, GST, CYP314, EcR and Vtg) and several enzymes (i.e. APND, ERND, GST and CAT) in a acute test (24 h). Results showed that high concentration (e.g. 50 μg L−1) of SV for short time exposure (e.g. 24 h) significantly induced the expression of HR96 and P-gp (e.g. up to 2.5 folds)and enzymes (e.g. increasing 4.0 folds for ERND and GST activity) in D. magna.. The long-term chronic exposure (21 days) may cause the changes of life history parameters such as decreasing total egg production number per individual and intrinsic growth rates etc. SV may act as a potential endocrine disruptor to D. magna and the reproduction parameters were more sensitive endpoints than the survival and growth for evaluating SV exposure." @default.
• W2953408035 created "2019-07-12" @default.
• W2953408035 creator A5002976916 @default.
• W2953408035 creator A5010071661 @default.
• W2953408035 creator A5023363049 @default.
• W2953408035 creator A5028859676 @default.
• W2953408035 creator A5080335185 @default.
• W2953408035 creator A5088745880 @default.
• W2953408035 date "2019-10-01" @default.
• W2953408035 modified "2023-10-05" @default.
• W2953408035 title "Simvastatin affect the expression of detoxification-related genes and enzymes in Daphnia magna and alter its life history parameters" @default.
• W2953408035 cites W1594406452 @default.
• W2953408035 cites W1806194750 @default.
• W2953408035 cites W1965805017 @default.
• W2953408035 cites W1979524489 @default.
• W2953408035 cites W1981939829 @default.
• W2953408035 cites W1999455728 @default.
• W2953408035 cites W2007972960 @default.
• W2953408035 cites W2014820285 @default.
• W2953408035 cites W2019125169 @default.
• W2953408035 cites W2025609229 @default.
• W2953408035 cites W2036881470 @default.
• W2953408035 cites W2042271211 @default.
• W2953408035 cites W2044911368 @default.
• W2953408035 cites W2047376147 @default.
• W2953408035 cites W2053471764 @default.
• W2953408035 cites W2057843079 @default.
• W2953408035 cites W2061533760 @default.
• W2953408035 cites W2061948833 @default.
• W2953408035 cites W2063028978 @default.
• W2953408035 cites W2065568958 @default.
• W2953408035 cites W2065775989 @default.
• W2953408035 cites W2071485403 @default.
• W2953408035 cites W2071523788 @default.
• W2953408035 cites W2087219235 @default.
• W2953408035 cites W2101627704 @default.
• W2953408035 cites W2107277218 @default.
• W2953408035 cites W2124565523 @default.
• W2953408035 cites W2124844398 @default.
• W2953408035 cites W2127967104 @default.
• W2953408035 cites W2133633242 @default.
• W2953408035 cites W2142693509 @default.
• W2953408035 cites W2329543325 @default.
• W2953408035 cites W2518806583 @default.
• W2953408035 cites W2562494462 @default.
• W2953408035 cites W2775929175 @default.
• W2953408035 cites W2790720163 @default.
• W2953408035 cites W279073025 @default.
• W2953408035 cites W4293247451 @default.
• W2953408035 doi "https://doi.org/10.1016/j.ecoenv.2019.109389" @default.
• W2953408035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31272027" @default.
• W2953408035 hasPublicationYear "2019" @default.
• W2953408035 type Work @default.
• W2953408035 sameAs 2953408035 @default.
• W2953408035 citedByCount "18" @default.
• W2953408035 countsByYear W29534080352019 @default.
• W2953408035 countsByYear W29534080352021 @default.
• W2953408035 countsByYear W29534080352022 @default.
• W2953408035 countsByYear W29534080352023 @default.
• W2953408035 crossrefType "journal-article" @default.
• W2953408035 hasAuthorship W2953408035A5002976916 @default.
• W2953408035 hasAuthorship W2953408035A5010071661 @default.
• W2953408035 hasAuthorship W2953408035A5023363049 @default.
• W2953408035 hasAuthorship W2953408035A5028859676 @default.
• W2953408035 hasAuthorship W2953408035A5080335185 @default.
• W2953408035 hasAuthorship W2953408035A5088745880 @default.
• W2953408035 hasConcept C126322002 @default.
• W2953408035 hasConcept C134018914 @default.
• W2953408035 hasConcept C142724271 @default.
• W2953408035 hasConcept C172269249 @default.
• W2953408035 hasConcept C18903297 @default.
• W2953408035 hasConcept C204787440 @default.
• W2953408035 hasConcept C2776329913 @default.
• W2953408035 hasConcept C2778208666 @default.
• W2953408035 hasConcept C2780158794 @default.
• W2953408035 hasConcept C2780187675 @default.
• W2953408035 hasConcept C2780497538 @default.
• W2953408035 hasConcept C2780862370 @default.
• W2953408035 hasConcept C29730261 @default.
• W2953408035 hasConcept C33070731 @default.
• W2953408035 hasConcept C46699223 @default.
• W2953408035 hasConcept C53164099 @default.
• W2953408035 hasConcept C59659247 @default.
• W2953408035 hasConcept C71315377 @default.
• W2953408035 hasConcept C71924100 @default.
• W2953408035 hasConcept C84766238 @default.
• W2953408035 hasConcept C86803240 @default.
• W2953408035 hasConcept C90856448 @default.
• W2953408035 hasConcept C98274493 @default.
• W2953408035 hasConceptScore W2953408035C126322002 @default.
• W2953408035 hasConceptScore W2953408035C134018914 @default.
• W2953408035 hasConceptScore W2953408035C142724271 @default.
• W2953408035 hasConceptScore W2953408035C172269249 @default.
• W2953408035 hasConceptScore W2953408035C18903297 @default.
• W2953408035 hasConceptScore W2953408035C204787440 @default.
• W2953408035 hasConceptScore W2953408035C2776329913 @default.
• W2953408035 hasConceptScore W2953408035C2778208666 @default.
• W2953408035 hasConceptScore W2953408035C2780158794 @default.

• next