FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953457921> ?p ?o ?g. }

• W2953457921 endingPage "640" @default.
• W2953457921 startingPage "629" @default.
• W2953457921 abstract "Chemotherapeutic drugs often used as a first-line treatment of pancreatic cancer (PC) exhibit challenges due to resistance development, lack of selectivity, and tumor heterogeneity. Currently, combination chemo-photothermal therapy is known to enhance the therapeutic efficacy of chemotherapeutic drugs in PC. In this study, we develop adherent gold nanoparticles (GNPs) and paclitaxel (PTX)-loaded PLGA microspheres for the treatment of PC. Polydopamine (pD) was used as a linker to adhere GNPs to the surface of PLGA-Ms and characterized using TEM. Short-term cytotoxicity of GNPs-pD-PTX-PLGA-Ms with or without NIR treatment was evaluated using CCK-8 assays. ROS and western blot assay were performed to determine the intensity of ROS following the treatment of GNPs-pD-PTX-PLGA-Ms with or without NIR in Panc-1 cell line. Successful adhesion of GNPs on the microspheres was confirmed by TEM. CCK-8 assay revealed that GNPs-pD-PTX-PLGA-Ms with NIR showed three-fold higher cytotoxicity, compared to the group without NIR. Furthermore, ROS and western blot assay suggest that GNPs-pD-PTX-PLGA-Ms with NIR showed more ROS generation, followed by downregulation of the expression levels of antioxidant enzyme (SOD2 and CATALASE). These results suggest that the GNPs-pD-PTX-PLGA-Ms in combination with NIR irradiation can provide a synergistic chemo-photothermal therapy for the treatment of PC." @default.
• W2953457921 created "2019-07-12" @default.
• W2953457921 creator A5008035486 @default.
• W2953457921 creator A5022659794 @default.
• W2953457921 creator A5025076154 @default.
• W2953457921 creator A5054869693 @default.
• W2953457921 date "2019-01-01" @default.
• W2953457921 modified "2023-10-17" @default.
• W2953457921 title "Polydopamine-tailored paclitaxel-loaded polymeric microspheres with adhered NIR-controllable gold nanoparticles for chemo-phototherapy of pancreatic cancer" @default.
• W2953457921 cites W105270587 @default.
• W2953457921 cites W1601953196 @default.
• W2953457921 cites W1968927007 @default.
• W2953457921 cites W1973681903 @default.
• W2953457921 cites W1974735351 @default.
• W2953457921 cites W1974922522 @default.
• W2953457921 cites W1987959156 @default.
• W2953457921 cites W1998380582 @default.
• W2953457921 cites W2004742654 @default.
• W2953457921 cites W2005079091 @default.
• W2953457921 cites W2007298573 @default.
• W2953457921 cites W2010796656 @default.
• W2953457921 cites W2024793632 @default.
• W2953457921 cites W2028464008 @default.
• W2953457921 cites W2029228838 @default.
• W2953457921 cites W2031298265 @default.
• W2953457921 cites W2037398945 @default.
• W2953457921 cites W2038466533 @default.
• W2953457921 cites W2045246542 @default.
• W2953457921 cites W2045456611 @default.
• W2953457921 cites W2052788642 @default.
• W2953457921 cites W2054870962 @default.
• W2953457921 cites W2055721190 @default.
• W2953457921 cites W2057492698 @default.
• W2953457921 cites W2060542391 @default.
• W2953457921 cites W2069360982 @default.
• W2953457921 cites W2070909089 @default.
• W2953457921 cites W2075318716 @default.
• W2953457921 cites W2087032263 @default.
• W2953457921 cites W2087997669 @default.
• W2953457921 cites W2092858957 @default.
• W2953457921 cites W2109637975 @default.
• W2953457921 cites W2117105709 @default.
• W2953457921 cites W2133123643 @default.
• W2953457921 cites W2135939338 @default.
• W2953457921 cites W2143021230 @default.
• W2953457921 cites W2143856400 @default.
• W2953457921 cites W2165418665 @default.
• W2953457921 cites W2169297538 @default.
• W2953457921 cites W2170202192 @default.
• W2953457921 cites W2182655233 @default.
• W2953457921 cites W2219588975 @default.
• W2953457921 cites W2250346307 @default.
• W2953457921 cites W2298332155 @default.
• W2953457921 cites W2322194440 @default.
• W2953457921 cites W2335405043 @default.
• W2953457921 cites W2339940212 @default.
• W2953457921 cites W2400588389 @default.
• W2953457921 cites W2406061066 @default.
• W2953457921 cites W2426902302 @default.
• W2953457921 cites W2488983675 @default.
• W2953457921 cites W2516284691 @default.
• W2953457921 cites W2524526846 @default.
• W2953457921 cites W2575428389 @default.
• W2953457921 cites W2579961151 @default.
• W2953457921 cites W2594387007 @default.
• W2953457921 cites W2726331924 @default.
• W2953457921 cites W2751111216 @default.
• W2953457921 cites W2753726306 @default.
• W2953457921 cites W2756185904 @default.
• W2953457921 cites W2764009809 @default.
• W2953457921 cites W2766897340 @default.
• W2953457921 cites W2781727981 @default.
• W2953457921 cites W2784261849 @default.
• W2953457921 cites W2789914639 @default.
• W2953457921 cites W2799938265 @default.
• W2953457921 cites W2857610659 @default.
• W2953457921 cites W2876116501 @default.
• W2953457921 cites W2889345093 @default.
• W2953457921 cites W2907200033 @default.
• W2953457921 cites W2911290679 @default.
• W2953457921 cites W2915660911 @default.
• W2953457921 cites W2923424658 @default.
• W2953457921 doi "https://doi.org/10.1080/10717544.2019.1628118" @default.
• W2953457921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6598510" @default.
• W2953457921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31237149" @default.
• W2953457921 hasPublicationYear "2019" @default.
• W2953457921 type Work @default.
• W2953457921 sameAs 2953457921 @default.
• W2953457921 citedByCount "39" @default.
• W2953457921 countsByYear W29534579212020 @default.
• W2953457921 countsByYear W29534579212021 @default.
• W2953457921 countsByYear W29534579212022 @default.
• W2953457921 countsByYear W29534579212023 @default.
• W2953457921 crossrefType "journal-article" @default.
• W2953457921 hasAuthorship W2953457921A5008035486 @default.
• W2953457921 hasAuthorship W2953457921A5022659794 @default.
• W2953457921 hasAuthorship W2953457921A5025076154 @default.
• W2953457921 hasAuthorship W2953457921A5054869693 @default.

• next