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• W2953458856 abstract "Abstract Background The aim was to study the association between allergic multimorbidity and adult‐onset asthma considering the number of allergic diseases and the age effect. Methods We used population‐based data from Finnish national registers including 1205 adults over 30 years of age with recently diagnosed asthma (age range: 30‐93), matched for gender, age, and living region with one or two controls (n = 2050). Allergic rhinitis (AR), allergic conjunctivitis (AC), and allergic dermatitis (AD) were defined from self‐completed questionnaire. Conditional logistic regression adjusted on potential confounders (smoking, growing in countryside, childhood hospitalized infection/pneumonia, parental asthma/allergy, parental smoking, education level, professional training, number of siblings, and birth order) was applied to estimate the asthma risk associated with allergic multimorbidity. Results A total of 1118 cases with asthma and 1772 matched controls were included [mean ( SD , min‐max) 53 (11, 31‐71) years, 37% men)]. AR, AC, and AD were reported by 50.2%, 39.6%, and 33.8%, respectively, among subjects with asthma and 26.1%, 20.0%, and 23.5%, respectively, among controls. Compared to nonatopics, adult‐onset asthma increased with the number of allergic diseases; adjusted OR for asthma [95% CI] associated with 1, 2, and 3 allergic diseases was 1.95 [1.52‐2.49], 2.87 [2.19‐3.77], and 4.26 [3.07‐5.90], respectively. The association between adult‐onset asthma and ≥ 1 allergic multimorbidity decreased with increasing age (3.52 [2.51‐4.94], 2.44 [1.74‐3.42], and 1.68 [1.04‐2.71]) in subjects < 50 years, 50‐62 years, and > 62 years, respectively (p for age*≥1 allergic multimorbidity interaction, 0.002). Conclusions Adult‐onset asthma was positively associated with the number of allergic diseases, and this association decreases with age." @default.
• W2953458856 created "2019-07-12" @default.
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• W2953458856 date "2019-07-24" @default.
• W2953458856 modified "2023-10-11" @default.
• W2953458856 title "Risk of adult‐onset asthma increases with the number of allergic multimorbidities and decreases with age" @default.
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• W2953458856 doi "https://doi.org/10.1111/all.13971" @default.
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