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• W2953469846 abstract "PURPOSE: The overweight/obesity affects brain function from cellular to structural levels, and due to the mitochondria importance, several studies have focused upon its involvement in the obesity and brain function. On rodents, previous data have already identified impairments of the prefrontal cortex triggered by obesity and its association with the oxidative stress. As the effect of moderate exercise training in the amelioration of the oxidative balance on prefrontal cortex was not examined in leptin-deficient ob/ob mice, this study assesses the effect of moderate physical exercise on oxidative stress parameters in the prefrontal cortex of leptin-deficient ob/ob mice. METHODS: Male ob/ob mice (Jackson Laboratories, Bar Harbor, ME, USA) with nine-weeks-old (32 g) were assigned into groups sedentary (S) and trained (T), housed in temperature and humidity controlled rooms, and kept on a 12 h light/dark cycle with food and water ad libitum. The physical training was performed at 60% of the maximal running capacity, 5 times/week, for 8 weeks. Forty-eight hours after last training, the animals were sacrificed and the prefrontal cortex quickly collected for oxidative balance analysis. RESULTS: We did not observe differences in the lipid (p=0.3285) and protein oxidation (p=0.3208) in leptin-deficient ob/ob exercised mice, with concomitant unchanging in the superoxide dismutase activity (p=0.2366) and catalase (p=0.7068). However, we observed that the physical training significantly increased glutathione-S-transferase activity (S: 0.93 ± 0.3 vs. T: 3.63 ± 0.8 U/mg prot; p=0.04). Moreover, the physical training increased the non-enzymatic antioxidant defense (GSH= S: 5.1 ± 0.3 vs. T: 6.4 ± 0.06 μM/mg prot, p=0.04; -SH levels= S:0.016 ± 0.003 vs T: 0.031 ± 0.001 mM/mg prot, p=0.02). Additionally, we evaluated the AMPK and PGC1a gene expression, and we observed that AMPK wasn´t modified after 8 weeks of physical training (p=0.86), however, PGC1a expression increased significantly (S: 1.00 ± 0.2 vs. T: 1.98 ± 0.20 ddCt; p=0.013). CONCLUSIONS: We suggest that physical exercise can minimize the detrimental effect of the obesity-induced oxidative stress in prefrontal cortex by activates an important transcriptor factor and possibly stimulates mitochondrial biogenesis." @default.
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• W2953469846 date "2019-06-01" @default.
• W2953469846 modified "2023-10-16" @default.
• W2953469846 title "Effect Of Physical Training In Leptin-deficient Ob/ob Mice: Oxidative Stress Evaluation In Prefrontal Cortex" @default.
• W2953469846 doi "https://doi.org/10.1249/01.mss.0000563446.61986.3f" @default.
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