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• W2953483865 abstract "Background In recent years advances in the field of pharmacogenomics have expanded the concept for more individualized treatments. Our aim is to provide literature data about the relationship between genetic polymorphisms and efficacy of antiepileptic drugs in children. Methods Pubmed was used as the main medical database source. Only original research papers were considered. No year-of-publication restriction was placed. Quality of evidence was assessed according to American Academy of Neurology guidelines. Results A total of 12 cross-sectional and case–control studies fulfilled our selection criteria. ABCB1 gene was associated with drug responsiveness in 2 out of 6 studies and ABCC2 gene in 1 out of 1 studies. SCN1A gene was also associated with seizure control in 4 out of 5 studies. Cytochrome P450 genes were found to significantly affect drug responsiveness in 2 out of 4 studies, while polymorphisms of uridinediphosphateglucuronosyltransferaseUGT2B7 gene predisposed to drug-resistance in 1 out of 2 studies. Conclusion Variability in genes coding for sodium channels, drug transporters and cytochrome P450 enzymes can have a significant impact on response to antiepileptic drugs. Larger prospective studies with better stratification of samples are needed to shed light on these associations." @default.
• W2953483865 created "2019-07-12" @default.
• W2953483865 creator A5010636366 @default.
• W2953483865 creator A5055429931 @default.
• W2953483865 date "2019-09-01" @default.
• W2953483865 modified "2023-09-30" @default.
• W2953483865 title "Efficacy of antiepileptic drugs in the era of pharmacogenomics: A focus on childhood" @default.
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• W2953483865 doi "https://doi.org/10.1016/j.ejpn.2019.06.004" @default.
• W2953483865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31280948" @default.
• W2953483865 hasPublicationYear "2019" @default.
• W2953483865 type Work @default.

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