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• W2953495739 endingPage "1488" @default.
• W2953495739 startingPage "1475" @default.
• W2953495739 abstract "Endocannabinoids and endocannabinoid-related compounds (ERCs) are involved in many physiological processes. They are released on demand from phosphoinositide and N-acylphosphatidyl ethanolamine (NAPE) precursors and comprise 2-monoacylglycerols (2-MGs) and FA ethanolamides (FEAs). Despite the abundance of advanced quantitative methods, however, their determined concentrations in blood plasma are inconsistent because 2-MGs and FEAs undergo artifactual de novo formation, chemical isomerization, and degradation during sample collection and storage. For a comprehensive survey of these compounds in blood and plasma, we have developed and validated an ultra-HPLC-MS/MS method to quantify 24 endocannabinoids, ERCs, and their phospholipid precursors. Immediate acidification of EDTA-blood to pH 5.8 blocked artifactual FEA formation for at least 4 h on ice. The 2-MGs were stabilized after plasma harvest with 0.5 M potassium thiocyanate at pH 4.7. FEA and MG plasma concentrations in six healthy volunteers ranged between 0.04-3.48 and 0.63-6.18 ng/ml, respectively. Interestingly, only 1-5% of circulating FEAs were present in their free form, while the majority was bound to NAPEs. Similarly, 97% of 2-arachidonoylglycerol (2-AG) was bound to a potential phosphoinositide pool. The herein-described stabilization and extraction methods may now be used to reliably and comprehensively quantify endocannabinoids, ERCs, and their phospholipid precursors in clinical studies." @default.
• W2953495739 created "2019-07-12" @default.
• W2953495739 creator A5039097280 @default.
• W2953495739 creator A5048455288 @default.
• W2953495739 creator A5065375120 @default.
• W2953495739 creator A5068682855 @default.
• W2953495739 date "2019-08-01" @default.
• W2953495739 modified "2023-10-14" @default.
• W2953495739 title "Quantification of 24 circulating endocannabinoids, endocannabinoid-related compounds, and their phospholipid precursors in human plasma by UHPLC-MS/MS" @default.
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• W2953495739 doi "https://doi.org/10.1194/jlr.d094680" @default.
• W2953495739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6672038" @default.
• W2953495739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31235475" @default.
• W2953495739 hasPublicationYear "2019" @default.
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