Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953497281> ?p ?o ?g. }
- W2953497281 endingPage "4780" @default.
- W2953497281 startingPage "4767" @default.
- W2953497281 abstract "Magnetic nanoparticles (MNPs) can be localized against hemodynamic forces in blood vessels with the application of an external magnetic field. In addition, PEGylation of nanoparticles may increase the half-life of nanocomposites in circulation. In this work, we examined the effect of PEGylation on the magnetic capture of MNPs in vivo.Laser speckle contrast imaging and capillaroscopy were used to assess the magnetic capture of dextran-coated MNPs and red blood cell (RBC) flow in cremaster microvessels of anesthetized rats. Magnetic capture of MNPs in serum flow was visualized with an in vitro circulating system. The effect of PEGylation on MNP-endothelial cell interaction was studied in cultured cells using an iron assay.In microcirculation through cremaster muscle, magnet-induced retention of 250 nm MNPs was associated with a variable reduction in RBC flow, suggesting a dynamic coupling of hemodynamic and magnetic forces. After magnet removal, faster restoration of flow was observed in PEG(+) than PEG(-) group, which may be attributed to a reduced interaction with vascular endothelium. However, PEGylation appears to be required for magnetic capture of 50 nm MNPs in microvessels, which was associated with increased hydrodynamic diameter to 130±6 nm in serum, but independent of the ς-potential.These results suggest that PEGylation may enhance magnetic capture of smaller MNPs and dispersion of larger MNPs after magnet removal, which may potentially affect the targeting, pharmacokinetics and therapeutic efficacy." @default.
- W2953497281 created "2019-07-12" @default.
- W2953497281 creator A5001557249 @default.
- W2953497281 creator A5022837724 @default.
- W2953497281 creator A5025689761 @default.
- W2953497281 creator A5080657441 @default.
- W2953497281 date "2019-07-01" @default.
- W2953497281 modified "2023-10-17" @default.
- W2953497281 title "<p>Effects of PEGylation on capture of dextran-coated magnetic nanoparticles in microcirculation</p>" @default.
- W2953497281 cites W1557094197 @default.
- W2953497281 cites W1823973466 @default.
- W2953497281 cites W1972835273 @default.
- W2953497281 cites W1975088956 @default.
- W2953497281 cites W1976915466 @default.
- W2953497281 cites W1977467418 @default.
- W2953497281 cites W1987026155 @default.
- W2953497281 cites W1990397068 @default.
- W2953497281 cites W1991098983 @default.
- W2953497281 cites W1997995247 @default.
- W2953497281 cites W2002528172 @default.
- W2953497281 cites W2002771831 @default.
- W2953497281 cites W2003706137 @default.
- W2953497281 cites W2025521007 @default.
- W2953497281 cites W2025531839 @default.
- W2953497281 cites W2033007989 @default.
- W2953497281 cites W2045115557 @default.
- W2953497281 cites W2047571912 @default.
- W2953497281 cites W2053006484 @default.
- W2953497281 cites W2054567871 @default.
- W2953497281 cites W2058972969 @default.
- W2953497281 cites W2059422902 @default.
- W2953497281 cites W2065879385 @default.
- W2953497281 cites W2066351250 @default.
- W2953497281 cites W2067827329 @default.
- W2953497281 cites W2068913529 @default.
- W2953497281 cites W2086968863 @default.
- W2953497281 cites W2091945030 @default.
- W2953497281 cites W2098922547 @default.
- W2953497281 cites W2123624166 @default.
- W2953497281 cites W2136226057 @default.
- W2953497281 cites W2136959343 @default.
- W2953497281 cites W2140310524 @default.
- W2953497281 cites W2143328804 @default.
- W2953497281 cites W2147725228 @default.
- W2953497281 cites W2154387381 @default.
- W2953497281 cites W2154824806 @default.
- W2953497281 cites W2257472368 @default.
- W2953497281 cites W2258635864 @default.
- W2953497281 cites W2304350979 @default.
- W2953497281 cites W2325692281 @default.
- W2953497281 cites W2344949123 @default.
- W2953497281 cites W2402319960 @default.
- W2953497281 cites W2409553453 @default.
- W2953497281 cites W2547186658 @default.
- W2953497281 cites W2580473658 @default.
- W2953497281 cites W2587287455 @default.
- W2953497281 cites W2590394007 @default.
- W2953497281 cites W2750917361 @default.
- W2953497281 cites W2790211976 @default.
- W2953497281 cites W2790350243 @default.
- W2953497281 cites W2923736255 @default.
- W2953497281 cites W619117458 @default.
- W2953497281 doi "https://doi.org/10.2147/ijn.s204844" @default.
- W2953497281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6613455" @default.
- W2953497281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31308657" @default.
- W2953497281 hasPublicationYear "2019" @default.
- W2953497281 type Work @default.
- W2953497281 sameAs 2953497281 @default.
- W2953497281 citedByCount "16" @default.
- W2953497281 countsByYear W29534972812019 @default.
- W2953497281 countsByYear W29534972812020 @default.
- W2953497281 countsByYear W29534972812021 @default.
- W2953497281 countsByYear W29534972812022 @default.
- W2953497281 countsByYear W29534972812023 @default.
- W2953497281 crossrefType "journal-article" @default.
- W2953497281 hasAuthorship W2953497281A5001557249 @default.
- W2953497281 hasAuthorship W2953497281A5022837724 @default.
- W2953497281 hasAuthorship W2953497281A5025689761 @default.
- W2953497281 hasAuthorship W2953497281A5080657441 @default.
- W2953497281 hasBestOaLocation W29534972811 @default.
- W2953497281 hasConcept C121332964 @default.
- W2953497281 hasConcept C12554922 @default.
- W2953497281 hasConcept C126838900 @default.
- W2953497281 hasConcept C12722491 @default.
- W2953497281 hasConcept C155672457 @default.
- W2953497281 hasConcept C171250308 @default.
- W2953497281 hasConcept C185592680 @default.
- W2953497281 hasConcept C192562407 @default.
- W2953497281 hasConcept C2776354463 @default.
- W2953497281 hasConcept C2776964284 @default.
- W2953497281 hasConcept C2777339698 @default.
- W2953497281 hasConcept C2779149719 @default.
- W2953497281 hasConcept C43617362 @default.
- W2953497281 hasConcept C46141821 @default.
- W2953497281 hasConcept C55493867 @default.
- W2953497281 hasConcept C71924100 @default.
- W2953497281 hasConcept C86803240 @default.
- W2953497281 hasConcept C87023908 @default.