FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953539506> ?p ?o ?g. }

• W2953539506 endingPage "1900056" @default.
• W2953539506 startingPage "1900056" @default.
• W2953539506 abstract "The search for biomarkers that can guide precision medicine in asthma, particularly those that can be translated to the clinic, has seen recent interest in exhaled volatile organic compounds (VOCs). Given the number of studies reporting breathomics findings and its growing integration in clinical trials, we performed a systematic review of the literature to summarise current evidence and understanding of breathomics technology in asthma.A PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)-oriented systematic search was performed (CRD42017084145) of MEDLINE, Embase and the Cochrane databases to search for any reports that assessed exhaled VOCs in adult asthma patients, using the following terms (asthma AND (volatile organic compounds AND exhaled) OR breathomics).Two authors independently determined the eligibility of 2957 unique records, of which 66 underwent full-text review. Data extraction and risk of bias assessment was performed on the 22 studies deemed to fulfil the search criteria. The studies are described in terms of methodology and the evidence narratively summarised under the following clinical headings: diagnostics, phenotyping, treatment stratification, treatment monitoring and exacerbation prediction/assessment.Our review found that most studies were designed to assess diagnostic potential rather than focus on underlying biology or treatable traits. Results are generally limited by a lack of methodological standardisation and external validation and by insufficiently powered studies, but there is consistency across the literature that exhaled VOCs are sensitive to underlying inflammation. Modern studies are applying robust breath analysis workflows to large multi-centre study designs, which should unlock the full potential of measurement of exhaled volatile organic compounds in airways diseases such as asthma." @default.
• W2953539506 created "2019-07-12" @default.
• W2953539506 creator A5036257231 @default.
• W2953539506 creator A5049904579 @default.
• W2953539506 creator A5053929091 @default.
• W2953539506 creator A5054055155 @default.
• W2953539506 creator A5089708209 @default.
• W2953539506 date "2019-07-04" @default.
• W2953539506 modified "2023-10-16" @default.
• W2953539506 title "Exhaled volatile organic compounds in adult asthma: a systematic review" @default.
• W2953539506 cites W159340952 @default.
• W2953539506 cites W1905949713 @default.
• W2953539506 cites W1963500742 @default.
• W2953539506 cites W1964514280 @default.
• W2953539506 cites W1964669406 @default.
• W2953539506 cites W1965495508 @default.
• W2953539506 cites W1965968853 @default.
• W2953539506 cites W1969139946 @default.
• W2953539506 cites W1981987797 @default.
• W2953539506 cites W1985196118 @default.
• W2953539506 cites W1989131633 @default.
• W2953539506 cites W1989697230 @default.
• W2953539506 cites W1996634690 @default.
• W2953539506 cites W1996772389 @default.
• W2953539506 cites W2002486849 @default.
• W2953539506 cites W2005943821 @default.
• W2953539506 cites W2006170372 @default.
• W2953539506 cites W2006259329 @default.
• W2953539506 cites W2007409836 @default.
• W2953539506 cites W2007698831 @default.
• W2953539506 cites W2010466187 @default.
• W2953539506 cites W2010806168 @default.
• W2953539506 cites W2022622856 @default.
• W2953539506 cites W2023002358 @default.
• W2953539506 cites W2025936978 @default.
• W2953539506 cites W2026250639 @default.
• W2953539506 cites W2027576789 @default.
• W2953539506 cites W2029242992 @default.
• W2953539506 cites W2030335543 @default.
• W2953539506 cites W2034662626 @default.
• W2953539506 cites W2036953109 @default.
• W2953539506 cites W2038145784 @default.
• W2953539506 cites W2040278225 @default.
• W2953539506 cites W2041049141 @default.
• W2953539506 cites W2045069984 @default.
• W2953539506 cites W2047035495 @default.
• W2953539506 cites W2048541209 @default.
• W2953539506 cites W2049442567 @default.
• W2953539506 cites W2049656505 @default.
• W2953539506 cites W2052625717 @default.
• W2953539506 cites W2057473960 @default.
• W2953539506 cites W2057526091 @default.
• W2953539506 cites W2058997735 @default.
• W2953539506 cites W2059647237 @default.
• W2953539506 cites W2061435251 @default.
• W2953539506 cites W2070674372 @default.
• W2953539506 cites W2074325744 @default.
• W2953539506 cites W2077217947 @default.
• W2953539506 cites W2077453857 @default.
• W2953539506 cites W2079529928 @default.
• W2953539506 cites W2082406884 @default.
• W2953539506 cites W2084194943 @default.
• W2953539506 cites W2085945130 @default.
• W2953539506 cites W2089236773 @default.
• W2953539506 cites W2090647630 @default.
• W2953539506 cites W2091265129 @default.
• W2953539506 cites W2094160988 @default.
• W2953539506 cites W2095754126 @default.
• W2953539506 cites W2098276532 @default.
• W2953539506 cites W2100799391 @default.
• W2953539506 cites W2102810061 @default.
• W2953539506 cites W2105787680 @default.
• W2953539506 cites W2106055476 @default.
• W2953539506 cites W2108110937 @default.
• W2953539506 cites W2109294649 @default.
• W2953539506 cites W2110143000 @default.
• W2953539506 cites W2114020518 @default.
• W2953539506 cites W2116555471 @default.
• W2953539506 cites W2122479103 @default.
• W2953539506 cites W2128242805 @default.
• W2953539506 cites W2131436543 @default.
• W2953539506 cites W2135906733 @default.
• W2953539506 cites W2137275746 @default.
• W2953539506 cites W2138438543 @default.
• W2953539506 cites W2138649409 @default.
• W2953539506 cites W2142856784 @default.
• W2953539506 cites W2143283561 @default.
• W2953539506 cites W2145188472 @default.
• W2953539506 cites W2149443601 @default.
• W2953539506 cites W2149888953 @default.
• W2953539506 cites W2150035260 @default.
• W2953539506 cites W2154263136 @default.
• W2953539506 cites W2160639342 @default.
• W2953539506 cites W2161525535 @default.
• W2953539506 cites W2167549681 @default.
• W2953539506 cites W2167829087 @default.
• W2953539506 cites W2171124311 @default.
• W2953539506 cites W2171404867 @default.

• next