FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953567314> ?p ?o ?g. }

• W2953567314 endingPage "97" @default.
• W2953567314 startingPage "81" @default.
• W2953567314 abstract "Animal models of aortic aneurysm and dissection can enhance our limited understanding of the etiology of these lethal conditions particularly because early-stage longitudinal data are scant in humans. Yet, the pathogenesis of often-studied mouse models and the potential contribution of aortic biomechanics therein remain elusive. In this work, we combined micro-CT and synchrotron-based imaging with computational biomechanics to estimate in vivo aortic strains in the abdominal aorta of angiotensin-II-infused ApoE-deficient mice, which were compared with mouse-specific aortic microstructural damage inferred from histopathology. Targeted histology showed that the 3D distribution of micro-CT contrast agent that had been injected in vivo co-localized with precursor vascular damage in the aortic wall at 3 days of hypertension, with damage predominantly near the ostia of the celiac and superior mesenteric arteries. Computations similarly revealed higher mechanical strain in branching relative to non-branching regions, thus resulting in a positive correlation between high strain and vascular damage in branching segments that included the celiac, superior mesenteric, and right renal arteries. These results suggest a mechanically driven initiation of damage at these locations, which was supported by 3D synchrotron imaging of load-induced ex vivo delaminations of angiotensin-II-infused suprarenal abdominal aortas. That is, the major intramural delamination plane in the ex vivo tested aortas was also near side branches and specifically around the celiac artery. Our findings thus support the hypothesis of an early mechanically mediated formation of microstructural defects at aortic branching sites that subsequently propagate into a macroscopic medial tear, giving rise to aortic dissection in angiotensin-II-infused mice." @default.
• W2953567314 created "2019-07-12" @default.
• W2953567314 creator A5007253257 @default.
• W2953567314 creator A5014119823 @default.
• W2953567314 creator A5014180482 @default.
• W2953567314 creator A5022201491 @default.
• W2953567314 creator A5025266813 @default.
• W2953567314 creator A5025470988 @default.
• W2953567314 creator A5036457394 @default.
• W2953567314 creator A5043532470 @default.
• W2953567314 date "2019-07-04" @default.
• W2953567314 modified "2023-10-15" @default.
• W2953567314 title "Co-localization of microstructural damage and excessive mechanical strain at aortic branches in angiotensin-II-infused mice" @default.
• W2953567314 cites W1964693177 @default.
• W2953567314 cites W1968974963 @default.
• W2953567314 cites W1970518087 @default.
• W2953567314 cites W1972838533 @default.
• W2953567314 cites W1980586741 @default.
• W2953567314 cites W1994893331 @default.
• W2953567314 cites W1995638322 @default.
• W2953567314 cites W2036067687 @default.
• W2953567314 cites W2055772387 @default.
• W2953567314 cites W2065203786 @default.
• W2953567314 cites W2071007487 @default.
• W2953567314 cites W2080373577 @default.
• W2953567314 cites W2083757081 @default.
• W2953567314 cites W2094876228 @default.
• W2953567314 cites W2119387276 @default.
• W2953567314 cites W2137850563 @default.
• W2953567314 cites W2140858016 @default.
• W2953567314 cites W2141579725 @default.
• W2953567314 cites W2159351650 @default.
• W2953567314 cites W2164721838 @default.
• W2953567314 cites W2168947486 @default.
• W2953567314 cites W2170948443 @default.
• W2953567314 cites W2178543889 @default.
• W2953567314 cites W2210225045 @default.
• W2953567314 cites W2237453233 @default.
• W2953567314 cites W2301329153 @default.
• W2953567314 cites W2405653653 @default.
• W2953567314 cites W2464319088 @default.
• W2953567314 cites W2545109774 @default.
• W2953567314 cites W2553521558 @default.
• W2953567314 cites W2587574387 @default.
• W2953567314 cites W2594653562 @default.
• W2953567314 cites W2730823572 @default.
• W2953567314 cites W2741650551 @default.
• W2953567314 cites W2749899920 @default.
• W2953567314 cites W2765697979 @default.
• W2953567314 cites W2767861327 @default.
• W2953567314 cites W2767999634 @default.
• W2953567314 cites W2799314395 @default.
• W2953567314 cites W2888876655 @default.
• W2953567314 cites W2890300091 @default.
• W2953567314 cites W2896238704 @default.
• W2953567314 cites W2896733436 @default.
• W2953567314 cites W2898337886 @default.
• W2953567314 cites W2903828519 @default.
• W2953567314 cites W4236756589 @default.
• W2953567314 cites W577916619 @default.
• W2953567314 doi "https://doi.org/10.1007/s10237-019-01197-3" @default.
• W2953567314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31273562" @default.
• W2953567314 hasPublicationYear "2019" @default.
• W2953567314 type Work @default.
• W2953567314 sameAs 2953567314 @default.
• W2953567314 citedByCount "9" @default.
• W2953567314 countsByYear W29535673142020 @default.
• W2953567314 countsByYear W29535673142021 @default.
• W2953567314 countsByYear W29535673142022 @default.
• W2953567314 countsByYear W29535673142023 @default.
• W2953567314 crossrefType "journal-article" @default.
• W2953567314 hasAuthorship W2953567314A5007253257 @default.
• W2953567314 hasAuthorship W2953567314A5014119823 @default.
• W2953567314 hasAuthorship W2953567314A5014180482 @default.
• W2953567314 hasAuthorship W2953567314A5022201491 @default.
• W2953567314 hasAuthorship W2953567314A5025266813 @default.
• W2953567314 hasAuthorship W2953567314A5025470988 @default.
• W2953567314 hasAuthorship W2953567314A5036457394 @default.
• W2953567314 hasAuthorship W2953567314A5043532470 @default.
• W2953567314 hasBestOaLocation W29535673142 @default.
• W2953567314 hasConcept C105702510 @default.
• W2953567314 hasConcept C126322002 @default.
• W2953567314 hasConcept C126838900 @default.
• W2953567314 hasConcept C150903083 @default.
• W2953567314 hasConcept C164705383 @default.
• W2953567314 hasConcept C192562407 @default.
• W2953567314 hasConcept C207001950 @default.
• W2953567314 hasConcept C26291073 @default.
• W2953567314 hasConcept C2776098176 @default.
• W2953567314 hasConcept C2777323849 @default.
• W2953567314 hasConcept C2779980429 @default.
• W2953567314 hasConcept C2779993416 @default.
• W2953567314 hasConcept C2908929049 @default.
• W2953567314 hasConcept C71924100 @default.
• W2953567314 hasConcept C84393581 @default.
• W2953567314 hasConcept C86803240 @default.
• W2953567314 hasConceptScore W2953567314C105702510 @default.
• W2953567314 hasConceptScore W2953567314C126322002 @default.

• next