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• W2953672501 abstract "Co-crystallization frequently employs forces such as hydrogen bonds, halogen bonds, and π-π stacking to assemble molecules in a multi-component crystal. In an effort to increase the strength of the intermolecular interaction between the anti-cholesterol drug bezafibrate (BEZA), a wastewater contaminant, and hydrogen-bond-acceptor molecules, we modified the pKa values of the acceptors. Here, we describe the first series of salts incorporating BEZA and achieve a variety of supramolecular architectures including discrete assemblies, 1D chains, tapes, and 2D sheets. We discuss exceptions to the pKa rule, and demonstrate that the presence of hydrogen-bond-donor atoms on the acceptor molecule supports salt formation." @default.
• W2953672501 created "2019-07-12" @default.
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• W2953672501 date "2019-07-01" @default.
• W2953672501 modified "2023-10-17" @default.
• W2953672501 title "Application of the pK_a rule to synthesize salts of bezafibrate" @default.
• W2953672501 cites W2011111095 @default.
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• W2953672501 doi "https://doi.org/10.1080/10610278.2019.1635695" @default.
• W2953672501 hasPublicationYear "2019" @default.
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