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• W2953674313 startingPage "e02020" @default.
• W2953674313 abstract "This work aimed to develop folic acid-functionalized nanostructured lipid carriers (NLC) loading epigallocatechin-3-gallate (EGCG) to increase its oral bioavailability. An active targeting strategy was used and these nanoparticles (NPs) were fully characterized. The NP's effect on Caco-2 cell viability was evaluated and the apparent permeability (Papp) on a Caco-2 cell monolayer was determined. The results demonstrated that the developed NPs exhibited adequate physicochemical characteristics for oral administration and were found to be biocompatible with epithelial Caco-2 cells. Further, folic acid-functionalized EGCG-loaded NLC significantly increased EGCG transport across the intestinal barrier, promoting a 1.8- fold increase in its apparent permeability (Papp). Taken together, these results support that the developed NLC can be used as a promising carrier for safer and efficient management of several diseases since the pharmacokinetic (PK) properties of EGCG were improved with this nanomedicine-based strategy." @default.
• W2953674313 created "2019-07-12" @default.
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• W2953674313 date "2019-07-01" @default.
• W2953674313 modified "2023-10-11" @default.
• W2953674313 title "EGCG intestinal absorption and oral bioavailability enhancement using folic acid-functionalized nanostructured lipid carriers" @default.
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• W2953674313 doi "https://doi.org/10.1016/j.heliyon.2019.e02020" @default.
• W2953674313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6611934" @default.
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