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• W2953695408 abstract "PURPOSE: As the survival rate of acute lymphoblastic leukemia continues to improve, it has been shown that survivors' exposure to chemotherapeutic agents leads to multiple long-term side effects. Thus, the decrease in the cardiorespiratory fitness of childhood acute lymphoblastic leukemia (ALL) survivors may be due to their cardiovascular response to the chemotherapeutic agents. The first aim of this study was to determine whether cardiorespiratory fitness and physical activity levels were lower among survivors than control subjects, while the second aim was to reported associations between genetic variants and cardiorespiratory fitness in survivors. METHODS: Cardiorespiratory fitness (VO2peak) and moderate to vigorous physical activity (MVPA) were compared between childhood ALL survivors (N=221) and control subjects (N=825). We performed whole-exome sequencing in survivors (N=239). Germline variants (both common and rare) in a selected set of genes (N=238) were analyzed for an association with cardiorespiratory fitness. RESULTS: A difference of 9.2mL·kg-1·min-1 for VO2peak between survivors and control subjects was observed. For an identical level of MVPA, the increase in VO2peak was different between the both studied cohorts. Also, the VO2peak decreased more rapidly with age among survivors, especially in females. Genetic association analyses showed that the common variant in the TTN gene was significantly associated with a low cardiorespiratory fitness level, while the LEPR, IGFBPI and ENO3 genes were significantly associated with a low cardiorespiratory fitness level in female survivors. Positive associations between the cardiorespiratory fitness level and trainability genes were mainly observed in females. CONCLUSIONS: For an identical level of MVPA in both survivors and control subjects, the cardiorespiratory fitness was significantly lower in survivors, which can be associated with variants in genes related to subjects’ trainability. These findings could allow better follow-ups tailored to survivors’ genetic profile and cardiorespiratory fitness. This study has important implications for survivors, physicians and researchers, which could help reduce at least some of the burden of long-term adverse effects of treatments." @default.
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• W2953695408 date "2019-06-01" @default.
• W2953695408 modified "2023-10-15" @default.
• W2953695408 title "Trainability Genes Provide Answers To The Cardiorespiratory Fitness Deficit In Childhood Acute Lymphoblastic Leukemia Survivors." @default.
• W2953695408 doi "https://doi.org/10.1249/01.mss.0000560975.70132.f3" @default.
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