FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953703798> ?p ?o ?g. }

• W2953703798 abstract "ABSTRACT The cytokines GM-CSF and IL-5 are thought to possess largely divergent functions despite a shared dependence on the common beta (β C ) chain to initiate signaling. Although IL-5 is part of the core type 2 cytokine signature and is required for protection against some helminths, it is dispensable for immunity to others, such as Heligmosomoides polygyrus bakeri ( H. polygyrus ). Whether this is due to compensatory mechanisms is unclear. The transcription factor Bhlhe40 has been shown to control GM-CSF production and is proposed to be a novel regulator of T helper type 2 cells. We have found that Bhlhe40 is required in T cells for a protective memory response to secondary H. polygyrus infection. H. polygyrus rechallenge elicited dramatic Bhlhe40-dependent changes in gene and cytokine expression by lamina propria CD4 + T cells and in vitro -polarized T H 2 cells, including induction of GM-CSF and maximal production of type 2 cytokines including IL-5. β C chain-deficient, but not GM-CSF-deficient, mice rechallenged with H. polygyrus had severely impaired protective immunity. Our results demonstrate that Bhlhe40 is an essential regulator of T H 2 cell immunity during helminth infection and reveal unexpected redundancy of β C chain-dependent cytokines." @default.
• W2953703798 created "2019-07-12" @default.
• W2953703798 creator A5011997919 @default.
• W2953703798 creator A5045664525 @default.
• W2953703798 creator A5046189285 @default.
• W2953703798 creator A5046391978 @default.
• W2953703798 creator A5050078845 @default.
• W2953703798 creator A5052310284 @default.
• W2953703798 creator A5054758763 @default.
• W2953703798 creator A5056860884 @default.
• W2953703798 creator A5057522992 @default.
• W2953703798 creator A5060685556 @default.
• W2953703798 creator A5079271676 @default.
• W2953703798 date "2019-07-02" @default.
• W2953703798 modified "2023-09-23" @default.
• W2953703798 title "Deficiency in Bhlhe40 impairs resistance toH. polygyrus bakeriand reveals novel Csf2rb-dependent regulation of anti-helminth immunity" @default.
• W2953703798 cites W1595377389 @default.
• W2953703798 cites W1602749129 @default.
• W2953703798 cites W1766627147 @default.
• W2953703798 cites W1943296744 @default.
• W2953703798 cites W1968254266 @default.
• W2953703798 cites W1977536320 @default.
• W2953703798 cites W1982713513 @default.
• W2953703798 cites W1991012007 @default.
• W2953703798 cites W2003084688 @default.
• W2953703798 cites W2007435978 @default.
• W2953703798 cites W2014672666 @default.
• W2953703798 cites W2018449740 @default.
• W2953703798 cites W2024100211 @default.
• W2953703798 cites W2029598083 @default.
• W2953703798 cites W2052068396 @default.
• W2953703798 cites W2069105390 @default.
• W2953703798 cites W2076510811 @default.
• W2953703798 cites W2100869499 @default.
• W2953703798 cites W2107168469 @default.
• W2953703798 cites W2125519695 @default.
• W2953703798 cites W2130410032 @default.
• W2953703798 cites W2131103018 @default.
• W2953703798 cites W2141897776 @default.
• W2953703798 cites W2151394355 @default.
• W2953703798 cites W2157837362 @default.
• W2953703798 cites W2159760583 @default.
• W2953703798 cites W2168632939 @default.
• W2953703798 cites W2169663073 @default.
• W2953703798 cites W2255304804 @default.
• W2953703798 cites W2398473974 @default.
• W2953703798 cites W2466626717 @default.
• W2953703798 cites W2520018378 @default.
• W2953703798 cites W2531186684 @default.
• W2953703798 cites W2550834483 @default.
• W2953703798 cites W2556561046 @default.
• W2953703798 cites W2568895515 @default.
• W2953703798 cites W2592449894 @default.
• W2953703798 cites W2593593231 @default.
• W2953703798 cites W2742795003 @default.
• W2953703798 cites W2763664029 @default.
• W2953703798 cites W2770743710 @default.
• W2953703798 cites W2794507069 @default.
• W2953703798 cites W2795629650 @default.
• W2953703798 cites W2801433675 @default.
• W2953703798 cites W2803146240 @default.
• W2953703798 cites W2804116873 @default.
• W2953703798 cites W2806926343 @default.
• W2953703798 cites W2900735818 @default.
• W2953703798 cites W2914518033 @default.
• W2953703798 cites W2939282416 @default.
• W2953703798 cites W2940004630 @default.
• W2953703798 cites W2942803502 @default.
• W2953703798 doi "https://doi.org/10.1101/687541" @default.
• W2953703798 hasPublicationYear "2019" @default.
• W2953703798 type Work @default.
• W2953703798 sameAs 2953703798 @default.
• W2953703798 citedByCount "0" @default.
• W2953703798 crossrefType "posted-content" @default.
• W2953703798 hasAuthorship W2953703798A5011997919 @default.
• W2953703798 hasAuthorship W2953703798A5045664525 @default.
• W2953703798 hasAuthorship W2953703798A5046189285 @default.
• W2953703798 hasAuthorship W2953703798A5046391978 @default.
• W2953703798 hasAuthorship W2953703798A5050078845 @default.
• W2953703798 hasAuthorship W2953703798A5052310284 @default.
• W2953703798 hasAuthorship W2953703798A5054758763 @default.
• W2953703798 hasAuthorship W2953703798A5056860884 @default.
• W2953703798 hasAuthorship W2953703798A5057522992 @default.
• W2953703798 hasAuthorship W2953703798A5060685556 @default.
• W2953703798 hasAuthorship W2953703798A5079271676 @default.
• W2953703798 hasBestOaLocation W29537037981 @default.
• W2953703798 hasConcept C104317684 @default.
• W2953703798 hasConcept C203014093 @default.
• W2953703798 hasConcept C2778690821 @default.
• W2953703798 hasConcept C2778885919 @default.
• W2953703798 hasConcept C2779341262 @default.
• W2953703798 hasConcept C2779727006 @default.
• W2953703798 hasConcept C54355233 @default.
• W2953703798 hasConcept C6929976 @default.
• W2953703798 hasConcept C86803240 @default.
• W2953703798 hasConcept C8891405 @default.
• W2953703798 hasConcept C95444343 @default.
• W2953703798 hasConceptScore W2953703798C104317684 @default.
• W2953703798 hasConceptScore W2953703798C203014093 @default.
• W2953703798 hasConceptScore W2953703798C2778690821 @default.

• next