FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953703923> ?p ?o ?g. }

• W2953703923 abstract "Classic dendritic cells (cDCs) play a central role in the immune system by processing and presenting antigens to activate T cells, and consist of two major subsets: CD141+ cDC (cDC1) and CD1c+ cDC (cDC2). A population of migratory precursor cells, the pre-cDCs, is the immediate precursors to both cDC subsets. Previous studies showed that there were two pre-committed pre-cDC subpopulations. However, the key molecular drivers of pre-commitment in human pre-cDCs were not investigated.To identify the key molecular drivers for pre-commitment in human pre-cDCs, we performed single cell RNA sequencing (RNA-Seq) of two cDC subsets and pre-cDCs, and bulk RNA-Seq of pre-cDCs and cDCs from human peripheral blood. We found that pre-DC subpopulations cannot be separated by either variable genes within pre-cDCs or differentially expressed genes between cDC1 and cDC2. In contrast, they were separated by 16 transcription factors that are themselves differentially expressed or have regulated targets enriched in the differentially expressed genes between bulk cDC1 and cDC2, with one subpopulation close to cDC1 and the other close to cDC2. More importantly, these two pre-cDC sub-populations are correlated with ratio of IRF8 to IRF4 expression level more than their individual expression level. We also verified these findings using three recently published datasets.In this study, we demonstrate that single cell transcriptome profiling can reveal pre-cDCs differentiation map, and our results suggest the concept that combinatorial dose of transcription factors determines cell differentiation fate." @default.
• W2953703923 created "2019-07-12" @default.
• W2953703923 creator A5004248570 @default.
• W2953703923 creator A5045570568 @default.
• W2953703923 creator A5048540174 @default.
• W2953703923 creator A5051115910 @default.
• W2953703923 creator A5051597447 @default.
• W2953703923 creator A5060245164 @default.
• W2953703923 creator A5066080208 @default.
• W2953703923 creator A5091612515 @default.
• W2953703923 date "2019-06-28" @default.
• W2953703923 modified "2023-10-18" @default.
• W2953703923 title "Single cell RNA-Seq reveals pre-cDCs fate determined by transcription factor combinatorial dose" @default.
• W2953703923 cites W1668035141 @default.
• W2953703923 cites W1742769645 @default.
• W2953703923 cites W1752957211 @default.
• W2953703923 cites W1909009992 @default.
• W2953703923 cites W1963740134 @default.
• W2953703923 cites W1965218665 @default.
• W2953703923 cites W1967327758 @default.
• W2953703923 cites W1968950760 @default.
• W2953703923 cites W1980942129 @default.
• W2953703923 cites W1981858801 @default.
• W2953703923 cites W2007706803 @default.
• W2953703923 cites W2010653277 @default.
• W2953703923 cites W2017138237 @default.
• W2953703923 cites W2018012763 @default.
• W2953703923 cites W2025828346 @default.
• W2953703923 cites W2035572849 @default.
• W2953703923 cites W2046505430 @default.
• W2953703923 cites W2050720713 @default.
• W2953703923 cites W2051658465 @default.
• W2953703923 cites W2070050178 @default.
• W2953703923 cites W2081924135 @default.
• W2953703923 cites W2096173332 @default.
• W2953703923 cites W2096539286 @default.
• W2953703923 cites W2102212449 @default.
• W2953703923 cites W2108822207 @default.
• W2953703923 cites W2110503722 @default.
• W2953703923 cites W2111435630 @default.
• W2953703923 cites W2117684305 @default.
• W2953703923 cites W2117757143 @default.
• W2953703923 cites W2118770646 @default.
• W2953703923 cites W2120315525 @default.
• W2953703923 cites W2121604817 @default.
• W2953703923 cites W2126705611 @default.
• W2953703923 cites W2133019048 @default.
• W2953703923 cites W2137586531 @default.
• W2953703923 cites W2138207763 @default.
• W2953703923 cites W2142084466 @default.
• W2953703923 cites W2153570621 @default.
• W2953703923 cites W2160443244 @default.
• W2953703923 cites W2168028214 @default.
• W2953703923 cites W2169456326 @default.
• W2953703923 cites W2179438025 @default.
• W2953703923 cites W2293973081 @default.
• W2953703923 cites W2384868473 @default.
• W2953703923 cites W2519385241 @default.
• W2953703923 cites W2556671754 @default.
• W2953703923 cites W2605810679 @default.
• W2953703923 cites W2610228741 @default.
• W2953703923 cites W2674242699 @default.
• W2953703923 cites W2747877289 @default.
• W2953703923 cites W2781617771 @default.
• W2953703923 cites W343298111 @default.
• W2953703923 doi "https://doi.org/10.1186/s12860-019-0199-y" @default.
• W2953703923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6599345" @default.
• W2953703923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31253076" @default.
• W2953703923 hasPublicationYear "2019" @default.
• W2953703923 type Work @default.
• W2953703923 sameAs 2953703923 @default.
• W2953703923 citedByCount "14" @default.
• W2953703923 countsByYear W29537039232019 @default.
• W2953703923 countsByYear W29537039232020 @default.
• W2953703923 countsByYear W29537039232021 @default.
• W2953703923 countsByYear W29537039232022 @default.
• W2953703923 countsByYear W29537039232023 @default.
• W2953703923 crossrefType "journal-article" @default.
• W2953703923 hasAuthorship W2953703923A5004248570 @default.
• W2953703923 hasAuthorship W2953703923A5045570568 @default.
• W2953703923 hasAuthorship W2953703923A5048540174 @default.
• W2953703923 hasAuthorship W2953703923A5051115910 @default.
• W2953703923 hasAuthorship W2953703923A5051597447 @default.
• W2953703923 hasAuthorship W2953703923A5060245164 @default.
• W2953703923 hasAuthorship W2953703923A5066080208 @default.
• W2953703923 hasAuthorship W2953703923A5091612515 @default.
• W2953703923 hasBestOaLocation W29537039231 @default.
• W2953703923 hasConcept C104317684 @default.
• W2953703923 hasConcept C107397762 @default.
• W2953703923 hasConcept C117705580 @default.
• W2953703923 hasConcept C120504264 @default.
• W2953703923 hasConcept C138885662 @default.
• W2953703923 hasConcept C144024400 @default.
• W2953703923 hasConcept C1491633281 @default.
• W2953703923 hasConcept C149923435 @default.
• W2953703923 hasConcept C150194340 @default.
• W2953703923 hasConcept C153911025 @default.
• W2953703923 hasConcept C162317418 @default.
• W2953703923 hasConcept C179926584 @default.
• W2953703923 hasConcept C2908647359 @default.

• next