FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953705715> ?p ?o ?g. }

• W2953705715 endingPage "1028" @default.
• W2953705715 startingPage "1022" @default.
• W2953705715 abstract "Objective: The effectiveness of anti-obesity medications (AOMs) outside of clinical trials is unclear. The objective of this study was to compare the short-term effectiveness of AOMs in real-world practice. Methods: This retrospective study included adults aged ≥18 years, with body mass index ≥30 kg/m2 or ≥27 kg/m2 with at least one obesity-related comorbidity who were prescribed phentermine hydrochloride, phenterminetopiramate, bupropion-naltrexone, or lorcaserin for 12 consecutive weeks between 2006 and 2016 at a large tertiary healthcare system. Propensity score–matched cohorts were created for each pair of AOMs. The primary outcomes were percent and absolute weight loss from baseline after 12 weeks. A prediction model was constructed to estimate weight loss with different AOMs based on demographic and clinical data. Results: Of the 3,411 patients included in this study, patients lost an average of 3.45% of body weight from baseline. All AOMs were associated with a significant weight loss from baseline (P<.0001). Patients lost the highest percentage of body weight on phentermine hydrochloride (3.75 ± 5.66%), followed by phentermine-topiramate (3.63 ± 5.7%), bupropion-naltrexone (2.66 ± 5.03%), and lorcaserin (1.84 ± 6.69%). In propensity-matched cohorts, patients taking phentermine hydrochloride lost more weight than those taking lorcaserin or bupropion-naltrexone, and patients taking phentermine topiramate lost more weight than patients taking lorcaserin. Conclusion: In real-world practice, AOMs are associated with clinically meaningful weight loss of 2 to 4% after 12 weeks. In this study, phentermine hydrochloride and phentermine topiramate produced the most weight loss. AOMs should be seriously considered as part of the armamentarium to treat patients with obesity. Abbreviations: AOM = anti-obesity medication; BMI = body mass index; EMR = electronic medical record; FDA = Food and Drug Administration; T2D = type 2 diabetes" @default.
• W2953705715 created "2019-07-12" @default.
• W2953705715 creator A5018414593 @default.
• W2953705715 creator A5022857377 @default.
• W2953705715 creator A5024615050 @default.
• W2953705715 creator A5029529314 @default.
• W2953705715 creator A5045859083 @default.
• W2953705715 creator A5054374857 @default.
• W2953705715 creator A5082147810 @default.
• W2953705715 creator A5089515974 @default.
• W2953705715 date "2019-10-01" @default.
• W2953705715 modified "2023-10-15" @default.
• W2953705715 title "The Benefit of Short-Term Weight Loss with Anti-Obesity Medications in Real-World Clinical Practice" @default.
• W2953705715 cites W1511363514 @default.
• W2953705715 cites W1762850481 @default.
• W2953705715 cites W2038409980 @default.
• W2953705715 cites W2096048424 @default.
• W2953705715 cites W2110438413 @default.
• W2953705715 cites W2136335834 @default.
• W2953705715 cites W2147648477 @default.
• W2953705715 cites W2152423343 @default.
• W2953705715 cites W2394582105 @default.
• W2953705715 cites W2411583672 @default.
• W2953705715 cites W2432501512 @default.
• W2953705715 cites W2470467325 @default.
• W2953705715 cites W2548768578 @default.
• W2953705715 cites W2746751342 @default.
• W2953705715 cites W2780530806 @default.
• W2953705715 cites W2789771787 @default.
• W2953705715 cites W2791300695 @default.
• W2953705715 cites W2890578584 @default.
• W2953705715 doi "https://doi.org/10.4158/ep-2019-0081" @default.
• W2953705715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31241358" @default.
• W2953705715 hasPublicationYear "2019" @default.
• W2953705715 type Work @default.
• W2953705715 sameAs 2953705715 @default.
• W2953705715 citedByCount "10" @default.
• W2953705715 countsByYear W29537057152021 @default.
• W2953705715 countsByYear W29537057152022 @default.
• W2953705715 countsByYear W29537057152023 @default.
• W2953705715 crossrefType "journal-article" @default.
• W2953705715 hasAuthorship W2953705715A5018414593 @default.
• W2953705715 hasAuthorship W2953705715A5022857377 @default.
• W2953705715 hasAuthorship W2953705715A5024615050 @default.
• W2953705715 hasAuthorship W2953705715A5029529314 @default.
• W2953705715 hasAuthorship W2953705715A5045859083 @default.
• W2953705715 hasAuthorship W2953705715A5054374857 @default.
• W2953705715 hasAuthorship W2953705715A5082147810 @default.
• W2953705715 hasAuthorship W2953705715A5089515974 @default.
• W2953705715 hasConcept C118552586 @default.
• W2953705715 hasConcept C126322002 @default.
• W2953705715 hasConcept C142724271 @default.
• W2953705715 hasConcept C2777683783 @default.
• W2953705715 hasConcept C2777843972 @default.
• W2953705715 hasConcept C2778186239 @default.
• W2953705715 hasConcept C2778456266 @default.
• W2953705715 hasConcept C2779908668 @default.
• W2953705715 hasConcept C2780221984 @default.
• W2953705715 hasConcept C2780586474 @default.
• W2953705715 hasConcept C511355011 @default.
• W2953705715 hasConcept C544821477 @default.
• W2953705715 hasConcept C71924100 @default.
• W2953705715 hasConceptScore W2953705715C118552586 @default.
• W2953705715 hasConceptScore W2953705715C126322002 @default.
• W2953705715 hasConceptScore W2953705715C142724271 @default.
• W2953705715 hasConceptScore W2953705715C2777683783 @default.
• W2953705715 hasConceptScore W2953705715C2777843972 @default.
• W2953705715 hasConceptScore W2953705715C2778186239 @default.
• W2953705715 hasConceptScore W2953705715C2778456266 @default.
• W2953705715 hasConceptScore W2953705715C2779908668 @default.
• W2953705715 hasConceptScore W2953705715C2780221984 @default.
• W2953705715 hasConceptScore W2953705715C2780586474 @default.
• W2953705715 hasConceptScore W2953705715C511355011 @default.
• W2953705715 hasConceptScore W2953705715C544821477 @default.
• W2953705715 hasConceptScore W2953705715C71924100 @default.
• W2953705715 hasIssue "10" @default.
• W2953705715 hasLocation W29537057151 @default.
• W2953705715 hasOpenAccess W2953705715 @default.
• W2953705715 hasPrimaryLocation W29537057151 @default.
• W2953705715 hasRelatedWork W1524509253 @default.
• W2953705715 hasRelatedWork W2000866847 @default.
• W2953705715 hasRelatedWork W2004929929 @default.
• W2953705715 hasRelatedWork W2052977571 @default.
• W2953705715 hasRelatedWork W2071828445 @default.
• W2953705715 hasRelatedWork W2084770204 @default.
• W2953705715 hasRelatedWork W3106887469 @default.
• W2953705715 hasRelatedWork W4294670757 @default.
• W2953705715 hasRelatedWork W4307757353 @default.
• W2953705715 hasRelatedWork W98828975 @default.
• W2953705715 hasVolume "25" @default.
• W2953705715 isParatext "false" @default.
• W2953705715 isRetracted "false" @default.
• W2953705715 magId "2953705715" @default.
• W2953705715 workType "article" @default.