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- W2953708001 abstract "The aim of this study was to compare the quantitative value of standardized uptake value (SUV) SUVmax obtained from F-18 FDG positron emission tomography/computed tomography (PET/CT) imaging of oncology patients with the cell-free DNA (cfDNA) amounts measured in plasma of patients and thus investigate if cfDNA is a significant marker to identify the presence of malignancy in the early period.A total of 184 patients were included in the study. The clinical, histopathologic, laboratory and treatment parameters were extracted from patient files. SUVmax and cfDNA quantities were assessedThere was no statistically significant difference in plasma cfDNA values between patient and control groups. The comparison of SUVmax and cfDNA values in the study showed that there was a weak correlation between SUVmaxand cfDNA. There was a significant difference between tumor size and SUVmax values. However, there was no statistically significant difference between tumor size and cfDNA.cfDNA measurements in the blood as a screening test have provided hope for early diagnosis and monitoring of cancer patients. Comparison of cfDNA levels obtained from plasma and quantitative parameters from PET/CT images of oncology patients in detailed advanced studies with larger patient series are required.Bu çalışmanın amacı, onkoloji hastalarında F-18 FDG pozitron emisyon tomografi/bilgisayarlı tomografi (PET/BT) görüntülemelerinden elde edilen standart tutulum değeri (SUV) SUVmaks’ın, hastaların plazmalarında ölçülen serbest DNA (cfDNA) miktarları ile kantitatif değerini karşılaştırmak ve böylece cfDNA’nın erken dönemde malignitenin varlığını tanımlamak için önemli bir belirteç olup olmadığını araştırmaktır.Çalışmaya toplam 184 hasta dahil edildi. Klinik durum, histopatolojik, laboratuvar ve tedavi parametreleri hasta dosyalarından araştırıldı. SUVmaks değeri ve cfDNA miktarları karşılaştırıldı.Hasta ve kontrol grubu arasında plazma cfDNA değerleri arasında istatistiksel olarak anlamlı fark yoktu. Araştırmada SUVmaks ve cfDNA değerlerinin karşılaştırılmasının sonucunda SUVmaks ve cfDNA arasında zayıf bir korelasyon vardı. Tümör boyutu ve SUVmaks değerleri arasında anlamlı bir fark bulundu. Bununla birlikte, tümör boyutu ve cfDNA arasında belirgin bir istatistiksel farklılık saptanmadı.Basit bir tarama testi olarak kullanılabilecek olan cfDNA ölçümleri kanser hastalarının erken tanı ve takiplerinde umut vaad etmektedir. Bu nedenle onkoloji hastalarının plazmalarından elde edilen cfDNA düzeyi ve PET/BT görüntülerinden elde edilen kantitatif parametrelerin karşılaştırıldığı daha büyük hasta serilerinde ve detaylı ileri çalışmalara ihtiyaç vardır." @default.
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- W2953708001 date "2019-06-01" @default.
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- W2953708001 title "Comparison of SUV<sub>max</sub> Values Obtained from F-18 FDG PET/CT and Cell-free DNA Levels Measured from Plasma in Oncology Patients" @default.
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- W2953708001 doi "https://doi.org/10.4274/mirt.galenos.2019.60352" @default.
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