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• W2953709867 abstract "Sleep has been hypothesized to rebalance overall synaptic strength after ongoing learning during waking leads to net synaptic potentiation. If so, because synaptic strength and size are correlated, synapses on average should be larger after wake and smaller after sleep. This prediction was recently confirmed in mouse cerebral cortex using serial block-face electron microscopy (SBEM). However, whether these findings extend to other brain regions is unknown. Moreover, sleep deprivation by gentle handling was reported to produce hippocampal spine loss, raising the question of whether synapse size and number are differentially affected by sleep and waking. Here we applied SBEM to measure axon-spine interface (ASI), the contact area between pre-synapse and post-synapse, and synapse density in CA1 stratum radiatum. Adolescent YFP-H mice were studied after 6-8 h of sleep (S = 6), spontaneous wake at night (W = 4) or wake enforced during the day by novelty exposure (EW = 4; males/females balanced). In each animal ≥425 ASIs were measured and synaptic vesicles were counted in ~100 synapses/mouse. Reconstructed dendrites included many small, nonperforated synapses and fewer large, perforated synapses. Relative to S, ASI sizes in perforated synapses shifted toward higher values after W and more so after EW. ASI sizes in nonperforated synapses grew after EW relative to S and W, and so did their density. ASI size correlated with presynaptic vesicle number but the proportion of readily available vesicles decreased after EW, suggesting presynaptic fatigue. Thus, CA1 synapses undergo changes consistent with sleep-dependent synaptic renormalization and their number increases after extended wake.SIGNIFICANCE STATEMENT Sleep benefits learning, memory consolidation, and the integration of new with old memories, but the underlying mechanisms remain highly debated. One hypothesis suggests that sleep's cognitive benefits stem from its ability to renormalize total synaptic strength, after ongoing learning during wake leads to net synaptic potentiation. Supporting evidence for this hypothesis mainly comes from the cerebral cortex, including the observation that cortical synapses are larger after wake and smaller after sleep. Using serial electron microscopy, we find here that sleep/wake synaptic changes consistent with sleep-dependent synaptic renormalization also occur in the CA1 region. Thus, the role of sleep in maintaining synaptic homeostasis may extend to the hippocampus, a key area for learning and synaptic plasticity." @default.
• W2953709867 created "2019-07-12" @default.
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• W2953709867 date "2019-07-01" @default.
• W2953709867 modified "2023-10-18" @default.
• W2953709867 title "Sleep Deprivation by Exposure to Novel Objects Increases Synapse Density and Axon–Spine Interface in the Hippocampal CA1 Region of Adolescent Mice" @default.
• W2953709867 cites W1513082520 @default.
• W2953709867 cites W1597375909 @default.
• W2953709867 cites W1597908762 @default.
• W2953709867 cites W1655792606 @default.
• W2953709867 cites W1798313689 @default.
• W2953709867 cites W1845163922 @default.
• W2953709867 cites W1872002431 @default.
• W2953709867 cites W1933979928 @default.
• W2953709867 cites W1967094886 @default.
• W2953709867 cites W1967745586 @default.
• W2953709867 cites W1967963204 @default.
• W2953709867 cites W1975401441 @default.
• W2953709867 cites W1977106703 @default.
• W2953709867 cites W1977647750 @default.
• W2953709867 cites W1983553517 @default.
• W2953709867 cites W1985392528 @default.
• W2953709867 cites W1986605182 @default.
• W2953709867 cites W1986900471 @default.
• W2953709867 cites W1987329720 @default.
• W2953709867 cites W1992156523 @default.
• W2953709867 cites W1995113307 @default.
• W2953709867 cites W2001528712 @default.
• W2953709867 cites W2001860569 @default.
• W2953709867 cites W2016756702 @default.
• W2953709867 cites W2024694517 @default.
• W2953709867 cites W2025605916 @default.
• W2953709867 cites W2026226894 @default.
• W2953709867 cites W2037889356 @default.
• W2953709867 cites W2039844429 @default.
• W2953709867 cites W2039969351 @default.
• W2953709867 cites W2040653138 @default.
• W2953709867 cites W2045436209 @default.
• W2953709867 cites W2046964445 @default.
• W2953709867 cites W2068027701 @default.
• W2953709867 cites W2068848753 @default.
• W2953709867 cites W2082246284 @default.
• W2953709867 cites W2083863715 @default.
• W2953709867 cites W2088880356 @default.
• W2953709867 cites W2090116050 @default.
• W2953709867 cites W2090516375 @default.
• W2953709867 cites W2091362970 @default.
• W2953709867 cites W2091752213 @default.
• W2953709867 cites W2097776322 @default.
• W2953709867 cites W2101234232 @default.
• W2953709867 cites W2104463303 @default.
• W2953709867 cites W2106766347 @default.
• W2953709867 cites W2109919607 @default.
• W2953709867 cites W2115750331 @default.
• W2953709867 cites W2117664079 @default.
• W2953709867 cites W2120587186 @default.
• W2953709867 cites W2127810309 @default.
• W2953709867 cites W2135208959 @default.
• W2953709867 cites W2135369850 @default.
• W2953709867 cites W2137096994 @default.
• W2953709867 cites W2138147085 @default.
• W2953709867 cites W2143377748 @default.
• W2953709867 cites W2143454033 @default.
• W2953709867 cites W2147762902 @default.
• W2953709867 cites W2151251384 @default.
• W2953709867 cites W2157744729 @default.
• W2953709867 cites W2159031677 @default.
• W2953709867 cites W2163895781 @default.
• W2953709867 cites W2167279371 @default.
• W2953709867 cites W2167725643 @default.
• W2953709867 cites W2195210638 @default.
• W2953709867 cites W2518307403 @default.
• W2953709867 cites W2583421592 @default.
• W2953709867 cites W2585275288 @default.
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• W2953709867 cites W2790696945 @default.
• W2953709867 cites W2794083194 @default.
• W2953709867 cites W2794305595 @default.
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• W2953709867 doi "https://doi.org/10.1523/jneurosci.0380-19.2019" @default.
• W2953709867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6703893" @default.
• W2953709867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31263066" @default.
• W2953709867 hasPublicationYear "2019" @default.
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