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- W2953714936 abstract "PURPOSE: Energy reserves for ambulation deteriorate progressively with age due to climbing energy costs and declining peak energy capacity. We examined whether declines in energy reserves necessary for gait contribute to brain atrophy. METHODS: We studied 597 cognitively-intact participants (mean age 69 years, 54% women) in the Baltimore Longitudinal Study of Aging neuroimaging study with repeated energetic and neuroimaging measures. Energy expenditure was measured using indirect calorimetry. Energetic reserve was defined as a cost ratio between the average VO2 (ml/kg/min) expended during a slow-paced (0.67 m/s) treadmill walking test and peak VO2 (ml/kg/min) expended during a rapid-paced 400m walk, with a higher cost ratio representing lower energetic reserve. Using MRI brain scans, brain volumes were derived using an automated multi-atlas approach to define regions-of-interest. Multivariable mixed-effects models were used to estimate whether: 1) baseline and 2) longitudinal changes in cost ratio were associated with annual changes in brain volumes. RESULTS: In fully-adjusted baseline models, a 10% higher baseline cost ratio was associated with a 0.18 cm3 (SE=0.04; p<0.001) annual increase in ventricular volume. Additionally, baseline cost ratio was inversely related to parahippocampal gyrus volume averaged over time (main effect=-0.05 (0.02) cm3, p=0.001). In fully-adjusted longitudinal models, an annual 10% increase in cost ratio was associated with a 0.04 (0.01) cm3 (p=0.002) annual decrease in parahippocampal gyrus volume. Though not statistically significant, increased cost ratios were observed with declines in all other regions. CONCLUSION: As the energetic cost of walking approaches energetic capacity, associated brain atrophy is explained by increased ventricle volume and shrinkage of the parahippocampal gyrus in cognitively-intact individuals. These findings suggest that declines in energy reserves may contribute to brain atrophy with aging." @default.
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- W2953714936 date "2019-06-01" @default.
- W2953714936 modified "2023-10-18" @default.
- W2953714936 title "Longitudinal Relationship between Energy Reserves and Brain Atrophy" @default.
- W2953714936 doi "https://doi.org/10.1249/01.mss.0000562345.17888.2f" @default.
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