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- W2953756075 endingPage "510" @default.
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- W2953756075 abstract "The blood-brain barrier (BBB) is an evolutionarily conserved, structural, and functional separation between circulating blood and the central nervous system (CNS). By controlling permeability into and out of the nervous system, the BBB has a critical role in the precise regulation of neural processes. Here, we review recent studies demonstrating that permeability at the BBB is dynamically controlled by circadian rhythms and sleep. An endogenous circadian rhythm in the BBB controls transporter function, regulating permeability across the BBB. In addition, sleep promotes the clearance of metabolites along the BBB, as well as endocytosis across the BBB. Finally, we highlight the implications of this regulation for diseases, including epilepsy." @default.
- W2953756075 created "2019-07-12" @default.
- W2953756075 creator A5002976445 @default.
- W2953756075 creator A5029627496 @default.
- W2953756075 creator A5062817134 @default.
- W2953756075 date "2019-07-01" @default.
- W2953756075 modified "2023-10-14" @default.
- W2953756075 title "Regulation of the Blood–Brain Barrier by Circadian Rhythms and Sleep" @default.
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- W2953756075 doi "https://doi.org/10.1016/j.tins.2019.05.001" @default.
- W2953756075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6602072" @default.
- W2953756075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31253251" @default.