Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953762188> ?p ?o ?g. }
- W2953762188 endingPage "3260" @default.
- W2953762188 startingPage "3260" @default.
- W2953762188 abstract "In recent decades, the elderly population has been rapidly increasing in many countries. Such patients are susceptible to Gram-negative septic shock, namely endotoxin shock. Mortality due to endotoxin shock remains high despite recent advances in medical care. The generalized Shwartzman reaction is well recognized as an experimental endotoxin shock. Aged mice are similarly susceptible to the generalized Shwartzman reaction and show an increased mortality accompanied by the enhanced production of tumor necrosis factor (TNF). Consistent with the findings in the murine model, the in vitro Shwartzman reaction-like response is also age-dependently augmented in human peripheral blood mononuclear cells, as assessed by enhanced TNF production. Interestingly, age-dependently increased innate lymphocytes with T cell receptor-that intermediate expression, such as that of CD8+CD122+T cells in mice and CD57+T cells in humans, may collaborate with macrophages and induce the exacerbation of the Shwartzman reaction in elderly individuals. However, endotoxin tolerance in mice, which resembles a mirror phenomenon of the generalized Shwartzman reaction, drastically reduces the TNF production of macrophages while strongly activating their bactericidal activity in infection. Importantly, this effect can be induced in aged mice. The safe induction of endotoxin tolerance may be a potential therapeutic strategy for refractory septic shock in elderly patients." @default.
- W2953762188 created "2019-07-12" @default.
- W2953762188 creator A5030001987 @default.
- W2953762188 creator A5052768130 @default.
- W2953762188 creator A5072750877 @default.
- W2953762188 creator A5076917742 @default.
- W2953762188 date "2019-07-02" @default.
- W2953762188 modified "2023-09-24" @default.
- W2953762188 title "Immune Mechanisms Underlying Susceptibility to Endotoxin Shock in Aged Hosts: Implication in Age-Augmented Generalized Shwartzman Reaction" @default.
- W2953762188 cites W136462 @default.
- W2953762188 cites W1480644042 @default.
- W2953762188 cites W1484554238 @default.
- W2953762188 cites W1537146394 @default.
- W2953762188 cites W1567817045 @default.
- W2953762188 cites W1572664742 @default.
- W2953762188 cites W1599518596 @default.
- W2953762188 cites W1608909099 @default.
- W2953762188 cites W1934337364 @default.
- W2953762188 cites W1976433008 @default.
- W2953762188 cites W1985694361 @default.
- W2953762188 cites W1987412927 @default.
- W2953762188 cites W1993197717 @default.
- W2953762188 cites W2005541017 @default.
- W2953762188 cites W2006027051 @default.
- W2953762188 cites W2006098035 @default.
- W2953762188 cites W2011026719 @default.
- W2953762188 cites W2011291552 @default.
- W2953762188 cites W2016429173 @default.
- W2953762188 cites W2028159810 @default.
- W2953762188 cites W2029466803 @default.
- W2953762188 cites W2030778014 @default.
- W2953762188 cites W2034714418 @default.
- W2953762188 cites W2035583085 @default.
- W2953762188 cites W2039251546 @default.
- W2953762188 cites W2040163024 @default.
- W2953762188 cites W2056554475 @default.
- W2953762188 cites W2062401561 @default.
- W2953762188 cites W2063591664 @default.
- W2953762188 cites W2082402714 @default.
- W2953762188 cites W2090023887 @default.
- W2953762188 cites W2090652473 @default.
- W2953762188 cites W2095138364 @default.
- W2953762188 cites W2098019283 @default.
- W2953762188 cites W2102872496 @default.
- W2953762188 cites W2103289907 @default.
- W2953762188 cites W2104415072 @default.
- W2953762188 cites W2105748362 @default.
- W2953762188 cites W2108473659 @default.
- W2953762188 cites W2123556794 @default.
- W2953762188 cites W2126263017 @default.
- W2953762188 cites W2129203245 @default.
- W2953762188 cites W2136387727 @default.
- W2953762188 cites W2141964465 @default.
- W2953762188 cites W2147383865 @default.
- W2953762188 cites W2151426785 @default.
- W2953762188 cites W2154332759 @default.
- W2953762188 cites W2160133043 @default.
- W2953762188 cites W2163454449 @default.
- W2953762188 cites W2164990391 @default.
- W2953762188 cites W2165112338 @default.
- W2953762188 cites W2165721969 @default.
- W2953762188 cites W2167923867 @default.
- W2953762188 cites W2169770330 @default.
- W2953762188 cites W2280404143 @default.
- W2953762188 cites W2313564746 @default.
- W2953762188 cites W2323894167 @default.
- W2953762188 cites W2326979296 @default.
- W2953762188 cites W2336770370 @default.
- W2953762188 cites W2346854449 @default.
- W2953762188 cites W2442246762 @default.
- W2953762188 cites W2462845880 @default.
- W2953762188 cites W2599142020 @default.
- W2953762188 cites W2599527603 @default.
- W2953762188 cites W2727765604 @default.
- W2953762188 cites W2755519540 @default.
- W2953762188 cites W2781664089 @default.
- W2953762188 cites W2891537049 @default.
- W2953762188 cites W2900032055 @default.
- W2953762188 cites W2903968772 @default.
- W2953762188 cites W2938380387 @default.
- W2953762188 cites W309833375 @default.
- W2953762188 cites W4230071474 @default.
- W2953762188 cites W4301177039 @default.
- W2953762188 cites W4313333873 @default.
- W2953762188 cites W66948318 @default.
- W2953762188 doi "https://doi.org/10.3390/ijms20133260" @default.
- W2953762188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6651521" @default.
- W2953762188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31269748" @default.
- W2953762188 hasPublicationYear "2019" @default.
- W2953762188 type Work @default.
- W2953762188 sameAs 2953762188 @default.
- W2953762188 citedByCount "7" @default.
- W2953762188 countsByYear W29537621882020 @default.
- W2953762188 countsByYear W29537621882021 @default.
- W2953762188 countsByYear W29537621882022 @default.
- W2953762188 countsByYear W29537621882023 @default.
- W2953762188 crossrefType "journal-article" @default.
- W2953762188 hasAuthorship W2953762188A5030001987 @default.